Evidence map›Paper›PMID 34825393›Full record

ArticleAmerican journal of industrial medicine2022

Autoimmune conditions in the World Trade Center general responder cohort: A nested case-control and standardized incidence ratio analysis.

Henry S Sacks, Margaret Smirnoff, Deborah Carson, Michael L Cooney, Moshe Z Shapiro, Christopher J Hahn, Christopher R Dasaro, Cynthia Crowson, Ioannis Tassiulas, Robert P Hirten and 12 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of industrial medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Henry S SacksDepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Margaret SmirnoffDepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Deborah CarsonDepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Michael L CooneyDepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, New York, USA.ORCID 0000-0001-7943-1951
Moshe Z ShapiroDepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Christopher J HahnDepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Christopher R DasaroDepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Cynthia CrowsonDivision of Biomedical Statistics and Informatics, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.
Ioannis TassiulasRheumatology Department, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Robert P HirtenRheumatology Department, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Benjamin L CohenRheumatology Department, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Richard S HaberRheumatology Department, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Terry F DaviesRheumatology Department, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
David M SimpsonRheumatology Department, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Michael A CraneDepartment of Environmental Medicine and Public Health, World Trade Center Health Program Clinical Center of Excellence, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Denise J HarrisonDepartment of Medicine, Department of Environmental Medicine, World Trade Center Health Program Clinical Center of Excellence, NYU Langone Medical Center, New York University School of Medicine, New York, New York, USA.
Benjamin J LuftDepartment of Medicine, World Trade Center Health Program Clinical Center of Excellence, Stony Brook University Medical Center, Stony Brook, New York, USA.
Jacqueline M MolineDepartment of Occupational Medicine, Epidemiology and Prevention, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, World Trade Center Health Program Clinical Center of Excellence, Hempstead, New York, USA.
Iris G UdasinDepartment of Environmental and Occupational Medicine, World Trade Center Health Program Clinical Center of Excellence, Environmental and Occupational Health Sciences Institute, Rutgers University Biomedical Sciences, Piscataway, New Jersey, USA.
Andrew C ToddDepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Nancy L SloanDepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, New York, USA.ORCID 0000-0002-3381-7602
Susan L TeitelbaumDepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

Funding

WTC Responder Health Consortium Clinical CenterU10OH008225 · OH · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI CRANE, MICHAEL ANTHONY · 2004 to 2010
$123.4M
Translational Research Support CoreP30ES005022 · NIEHS · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI HELMUT ZARBL · 1988 to 2026
$47.4M
Clinical Services for World Trade Center RespondersU10OH008216 · OH · STATE UNIVERSITY NEW YORK STONY BROOK · PI LUFT, BENJAMIN J · 2004 to 2010
$34.9M
WTC RHC Data and Coordination CenterU10OH008232 · OH · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI LANDRIGAN, PHILIP J · 2004 to 2010
$26.1M
World Trade Center Monitoring and Treatment ProgramU10OH008239 · OH · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI UDASIN, IRIS GREENBERG · 2004 to 2012
$12.0M
WTC Screening, Monitoring, and Treatment ProgramU10OH008223 · OH · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI HARRISON, DENISE · 2004 to 2010
$6.0M
Interdisciplinary Infrastructure for Aging Research: Rochester Epidemiology ProjectR33AG058738 · NIA · MAYO CLINIC ROCHESTER · PI LEBRASSEUR, NATHAN K, OLSON, JANET E · 2020 to 2022
$2.4M
Digital Biomarkers of Ulcerative Colitis FlareK23DK129835 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI HIRTEN, ROBERT · 2021 to 2025
$812k
CDC HHS HHSD200201139356CCDC HHS HHSD200201139361CCDC HHS HHSD200201139384CCDC HHS HHSD200201139385CCDC HHS HHSD200201139388CNIA NIH HHS R33 AG058738NIDDK NIH HHS K23 DK129835NIEHS NIH HHS P30 ES005022NIOSH CDC HHS 200-2002-00384NIOSH CDC HHS 200-2011-39356/61/77/84/85/88NIOSH CDC HHS 200-2017-93325NIOSH CDC HHS HHSD200200200384CNIOSH CDC HHS HHSD200201139377CNIOSH CDC HHS HHSD200201793325CNIOSH CDC HHS U10 OH008216NIOSH CDC HHS U10-OH008216/23/25/32/39/75NIOSH CDC HHS U10 OH008223NIOSH CDC HHS U10 OH008225NIOSH CDC HHS U10 OH008232NIOSH CDC HHS U10 OH008239
6 · The paper itself

Abstract

backgroundThe World Trade Center (WTC) general responder cohort (GRC) was exposed to environmental toxins possibly associated with increased risk of developing autoimmune conditions.

objectivesTwo study designs were used to assess incidence and risks of autoimmune conditions in the GRC.

methodsThree clinically trained professionals established the status of possible GRC cases of autoimmune disorders adhering to diagnostic criteria, supplemented, as needed, by specialists' review of consenting responders' medical records. Nested case-control analyses using conditional logistic regression estimated the risk associated with high WTC exposure (being in the 9/11/2001 dust cloud or ≥median days' response worked) compared with low WTC exposure (all other GRC members'). Four controls were matched to each case on age at case diagnosis (±2 years), sex, race/ethnicity, and year of program enrollment. Sex-specific and sensitivity analyses were performed. GRC age- and sex-adjusted standardized incidence ratios (SIRs) were compared with the Rochester Epidemiology Project (REP). Complete REP inpatient and outpatient medical records were reviewed by specialists. Conditions meeting standardized criteria on ≥2 visits were classified as REP confirmed cases.

resultsSix hundred and twenty-eight responders were diagnosed with autoimmune conditions between 2002 and 2017. In the nested case-control analyses, high WTC exposure was not associated with autoimmune domains and conditions (rheumatologic domain odds ratio [OR] = 1.03, 95% confidence interval [CI] = 0.77, 1.37; rheumatoid arthritis OR = 1.12, 95% CI = 0.70, 1.77). GRC members had lower SIR than REP. Women's risks were generally greater than men's.

conclusionsThe study found no statistically significant increased risk of autoimmune conditions with WTC exposures.

Indexed as

Autoimmune DiseasesEmergency RespondersOccupational ExposureSeptember 11 Terrorist AttacksCase-Control StudiesFemaleHumansIncidenceMaleNew York Cityautoimmune conditionsenvironmental exposureresponder/recovery workerWorld Trade Center

Identifiers

PMID34825393
PMCPMC8851411

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