Evidence map›Paper›PMID 34825342›Full record

ArticleHuman cell2022

USP21 regulates Hippo signaling to promote radioresistance by deubiquitinating FOXM1 in cervical cancer.

Zhengliang Li, Xiaojing Liu, Haizhou Yu, Shaoping Wang, Shuliang Zhao, Guoxiang Jiang

Abstract read
PubMed Publisher
In one paragraph

Article in Human cell, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.

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  18. A review of deubiquitinases and thier roles in tumorigenesis and development.Frontiers in bioengineering and biotechnology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Zhengliang Li *Department of Radiotherapy, Yantaishan Hospital, No. 10087 Science and Technology Avenue, Laishan District, Yantai, Shandong, China.
Xiaojing Liu *Department of Traditional Chinese Medicine, Yantai Center for Food and Drug Control, Yantai, Shandong, China.
Haizhou YuDepartment of Pharmacology and Toxicology, Yantai Center for Food and Drug Control, Yantai, Shandong, China.
Shaoping WangSchool of Pharmacy, Binzhou Medical University, Yantai, Shandong, China.
Shuliang ZhaoDepartment of Radiotherapy, Yantaishan Hospital, No. 10087 Science and Technology Avenue, Laishan District, Yantai, Shandong, China.
Guoxiang JiangDepartment of Radiotherapy, Yantaishan Hospital, No. 10087 Science and Technology Avenue, Laishan District, Yantai, Shandong, China. xiangdane8384@126.com.
Yantaishan Hospital · CNBinzhou Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The ectopic expression of ubiquitin-specific peptidase 21 (USP21) is common in different types of cancer. However, its relationship with radio-sensitivity in cervical cancer (CC) remains unclear. In this study, we aimed to uncover the effect of USP21 on CC radio-resistance and its underlying mechanism. Our results showed that the expression of USP21 was markedly increased in CC tissues of radio-resistant patients and CC cells treated with radiation. Besides, knockdown of USP21 restrained the survival fractions, and facilitated apoptosis of CC cells in the absence or presence of radiation. Additionally, USP21 in combination with FOXM1 regulated the stability and ubiquitination of FOXM1. However, FOXM1 reversed the effects of USP21 knockdown on the radio-resistance of CC cells. Furthermore, FOXM1 knockdown activated the Hippo pathway by inhibiting the nuclear translocation of Yes-associated protein 1 (YAP1), and FOXM1 knockdown attenuated the radio-resistance of CC cells via inhibiting the Hippo-YAP1 pathway. USP21 activated the Hippo pathway by mediating FOXM1. Knockdown of USP21 enhanced the radio-sensitivity of CC cells in vivo. In summary, USP21 contributed to the radio-resistance of CC cells via FOXM1/Hippo signaling, and may serve as a promising target for radio-sensitizers in the radiotherapy of CC.

Indexed as

UbiquitinationCell Line, TumorFemaleForkhead Box Protein M1Gene Expression Regulation, NeoplasticHippo Signaling PathwayHumansRadiation-Sensitizing AgentsRadiation ToleranceUbiquitin ThiolesteraseUterine Cervical NeoplasmsYAP-Signaling ProteinsForkhead Box Protein M1FOXM1 protein, humanRadiation-Sensitizing AgentsUbiquitin ThiolesteraseUSP21 protein, humanYAP1 protein, humanYAP-Signaling ProteinsCervical cancerHippo–YAP1 signalingRadioresistanceUbiquitinationUSP21

Identifiers

PMID34825342
OpenAlexW3217203778

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.