Evidence map›Paper›PMID 34825263›Full record

ArticleArchives of osteoporosis2021

Peripheral quantitative computed tomography (pQCT) measures are associated with prior low trauma fracture in men.

Kara B Anderson, Monica C Tembo, Sophia X Sui, Natalie K Hyde, Julie A Pasco, Mark A Kotowicz, Kara L Holloway-Kew

Abstract read
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In one paragraph

Article in Archives of osteoporosis, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 80% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Use of DXA-derived 3D-modeling, as implemented by 3D-Shaper, for the assessment of fracture risk in a population-based setting.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2026
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Kara B AndersonEpi-Centre for Healthy Ageing (ECHA), IMPACT (Institute for Mental and Physical Health and Clinical Translation), Deakin University, PO Box 281, Barwon Health, Geelong, VIC, 3220, Australia. k.anderson@deakin.edu.au.
Monica C TemboEpi-Centre for Healthy Ageing (ECHA), IMPACT (Institute for Mental and Physical Health and Clinical Translation), Deakin University, PO Box 281, Barwon Health, Geelong, VIC, 3220, Australia.
Sophia X SuiEpi-Centre for Healthy Ageing (ECHA), IMPACT (Institute for Mental and Physical Health and Clinical Translation), Deakin University, PO Box 281, Barwon Health, Geelong, VIC, 3220, Australia.
Natalie K HydeEpi-Centre for Healthy Ageing (ECHA), IMPACT (Institute for Mental and Physical Health and Clinical Translation), Deakin University, PO Box 281, Barwon Health, Geelong, VIC, 3220, Australia.
Julie A PascoEpi-Centre for Healthy Ageing (ECHA), IMPACT (Institute for Mental and Physical Health and Clinical Translation), Deakin University, PO Box 281, Barwon Health, Geelong, VIC, 3220, Australia.
Mark A KotowiczEpi-Centre for Healthy Ageing (ECHA), IMPACT (Institute for Mental and Physical Health and Clinical Translation), Deakin University, PO Box 281, Barwon Health, Geelong, VIC, 3220, Australia.
Kara L Holloway-KewEpi-Centre for Healthy Ageing (ECHA), IMPACT (Institute for Mental and Physical Health and Clinical Translation), Deakin University, PO Box 281, Barwon Health, Geelong, VIC, 3220, Australia.
Barwon Health · AUDeakin University · AUUniversity of Melbourne · AU

Funding

National Health and Medical Research Council 251638, 299831, 628582
6 · The paper itself

Abstract

Peripheral quantitative computed tomography (pQCT) assesses bone quantity and quality, complementary to current standard practice, and has potential to improve prediction of fracture risk. This study explored whether pQCT parameters were associated with prior fracture in men and found a number of parameters to be associated, particularly at the radius. PURPOSE: Peripheral quantitative computed tomography (pQCT) provides information about bone structure and density complementary to dual x-ray absorptiometry. This study aimed to determine which pQCT parameters are associated with prior fracture.

methodsParticipants were men (n = 508, age 33-96 years) from the Geelong Osteoporosis Study. Parameters at 4% (n = 469) and 66% (n = 436) of radial length, and 4% (n = 449) and 66% (n = 437) of tibial length were acquired (pQCT XCT 2000, Stratec Medizintechnik, Pforzheim, Germany), and mean standardised. Low trauma prior fractures in adulthood (≥ age 20 years) were radiologically confirmed when possible. Cross-sectional associations between pQCT and fracture were tested using logistic regression adjusting for confounders.

resultsPrior low trauma fractures were identified for 106 participants. Fracture was negatively associated with parameters at the 4% radius site: bone mass (adjusted OR = 0.67; 95%CI = 0.52-0.86), total density (OR = 0.61; 95%CI = 0.47-0.78), trabecular density (OR = 0.62; 95%CI = 0.48-0.79) and cortical subdensity (OR = 0.61; 95%CI = 0.47-0.77). At the 66% radius site, fracture was associated with total density (OR = 0.69; 95%CI = 0.55-0.87) and cortical thickness (OR = 0.68; 95%CI = 0.54-0.86). Fracture was associated with the ratio of the cortical area at the 66% site to the total area at the 4% site (OR = 0.74; 95%CI = 0.58-0.94). Prior fracture was negatively associated with parameters at the 4% tibial site: total density (OR = 0.67; 95%CI = 0.52-0.86), trabecular density (OR = 0.64; 95%CI = 0.50-0.82) and cortical subdensity (OR = 0.72; 95%CI = 0.56-0.92). Fracture was negatively associated with cortical density at the 66% site (OR = 0.74; 95%CI = 0.58-0.94), and the ratio of the cortical area at the 66% site to the total area at the 4% site (OR = 0.65; 95%CI = 0.46-0.91), but were attenuated in adjusted models. No other associations were identified.

conclusionPrior fracture was associated with parameters at both the radius and tibia. This study highlights key pQCT parameters that may aid in the prediction of fracture risk.

Indexed as

Osteoporotic FracturesAbsorptiometry, PhotonAdultAgedAged, 80 and overBone DensityCross-Sectional StudiesHumansMaleMiddle AgedRadiusTibiaTomography, X-Ray ComputedYoung AdultFractureHealthy ageingMenPeripheral quantitative computed tomography (pQCT)

Identifiers

PMID34825263
OpenAlexW3215734409

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.