Evidence map›Paper›PMID 34825187›Full record

ArticleRSC medicinal chemistry2021

Synthesis and antitumour evaluation of indole-2-carboxamides against paediatric brain cancer cells.

Shahinda S R Alsayed, Amreena Suri, Anders W Bailey, Samuel Lane, Eryn L Werry, Chiang-Ching Huang, Li-Fang Yu, Michael Kassiou, Simone Treiger Sredni, Hendra Gunosewoyo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RSC medicinal chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Secreted Phospholipases A2: Drivers of Inflammation and Cancer.International journal of molecular sciences · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Shahinda S R AlsayedCurtin Medical School, Faculty of Health Sciences, Curtin University Bentley Perth WA 6102 Australia Hendra.Gunosewoyo@curtin.edu.au.ORCID https://orcid.org/0000-0003-0277-255X
Amreena SuriDivision of Pediatric Neurosurgery, Ann and Robert H. Lurie Children's Hospital of Chicago Chicago IL 60611 USA simone.sredni@gmail.com.
Anders W BaileyDivision of Pediatric Neurosurgery, Ann and Robert H. Lurie Children's Hospital of Chicago Chicago IL 60611 USA simone.sredni@gmail.com.
Samuel LaneSchool of Chemistry, The University of Sydney NSW 2006 Australia michael.kassiou@sydney.edu.au.
Eryn L WerrySchool of Chemistry, The University of Sydney NSW 2006 Australia michael.kassiou@sydney.edu.au.
Chiang-Ching HuangDepartment of Biostatistics, Zilber School of Public Health, University of Wisconsin Milwaukee WI 53205 USA.
Li-Fang YuShanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University 3663 North Zhongshan Road Shanghai 200062 China.
Michael KassiouSchool of Chemistry, The University of Sydney NSW 2006 Australia michael.kassiou@sydney.edu.au.ORCID https://orcid.org/0000-0002-6655-0529
Simone Treiger SredniDivision of Pediatric Neurosurgery, Ann and Robert H. Lurie Children's Hospital of Chicago Chicago IL 60611 USA simone.sredni@gmail.com.
Hendra GunosewoyoCurtin Medical School, Faculty of Health Sciences, Curtin University Bentley Perth WA 6102 Australia Hendra.Gunosewoyo@curtin.edu.au.ORCID https://orcid.org/0000-0003-3897-1948

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Paediatric glioblastomas are rapidly growing, devastating brain neoplasms with an invasive phenotype. Radiotherapy and chemotherapy, which are the current therapeutic adjuvant to surgical resection, are still associated with various toxicity profiles and only marginally improve the course of the disease and life expectancy. A considerable body of evidence supports the antitumour and apoptotic effects of certain cannabinoids, such as WIN55,212-2, against a wide spectrum of cancer cells, including gliomas. In fact, we previously highlighted the potent cytotoxic activity of the cannabinoid ligand

Identifiers

PMID34825187
PMCPMC8597418

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.