Evidence map›Paper›PMID 34825186›Full record

ArticleRSC medicinal chemistry2021

Structure-based design of haloperidol analogues as inhibitors of acetyltransferase Eis from

Ankita Punetha, Keith D Green, Atefeh Garzan, Nishad Thamban Chandrika, Melisa J Willby, Allan H Pang, Caixia Hou, Selina Y L Holbrook, Kyle Krieger, James E Posey and 3 more

Open access · greenAbstract read
In one paragraph

Article in RSC medicinal chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. NProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  3. Epigenetic Mechanisms Induced byInternational journal of molecular sciences · 2024
    Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. HowFrontiers in cellular and infection microbiology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Ankita PunethaDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky 789 South Limestone Street Lexington KY 40536 USA oleg.tsodikov@uky.edu sylviegtsodikova@uky.edu.
Keith D GreenDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky 789 South Limestone Street Lexington KY 40536 USA oleg.tsodikov@uky.edu sylviegtsodikova@uky.edu.
Atefeh GarzanDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky 789 South Limestone Street Lexington KY 40536 USA oleg.tsodikov@uky.edu sylviegtsodikova@uky.edu.
Nishad Thamban ChandrikaDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky 789 South Limestone Street Lexington KY 40536 USA oleg.tsodikov@uky.edu sylviegtsodikova@uky.edu.
Melisa J WillbyLaboratory Branch, Division of Tuberculosis Elimination, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention Atlanta GA 30329 USA.
Allan H PangDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky 789 South Limestone Street Lexington KY 40536 USA oleg.tsodikov@uky.edu sylviegtsodikova@uky.edu.ORCID https://orcid.org/0000-0003-4786-6445
Caixia HouDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky 789 South Limestone Street Lexington KY 40536 USA oleg.tsodikov@uky.edu sylviegtsodikova@uky.edu.
Selina Y L HolbrookDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky 789 South Limestone Street Lexington KY 40536 USA oleg.tsodikov@uky.edu sylviegtsodikova@uky.edu.
Kyle KriegerCenter for Global Infectious Disease Research, Seattle Children's Research Institute 307 Westlake Avenue N Seattle WA 98109 USA.
James E PoseyLaboratory Branch, Division of Tuberculosis Elimination, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention Atlanta GA 30329 USA.
Tanya ParishCenter for Global Infectious Disease Research, Seattle Children's Research Institute 307 Westlake Avenue N Seattle WA 98109 USA.ORCID https://orcid.org/0000-0001-7507-0423
Oleg V TsodikovDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky 789 South Limestone Street Lexington KY 40536 USA oleg.tsodikov@uky.edu sylviegtsodikova@uky.edu.ORCID https://orcid.org/0000-0001-7094-4216
Sylvie Garneau-TsodikovaDepartment of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky 789 South Limestone Street Lexington KY 40536 USA oleg.tsodikov@uky.edu sylviegtsodikova@uky.edu.ORCID https://orcid.org/0000-0002-7961-5555
University of Kentucky · USCenters for Disease Control and Prevention · US

Funding

Novel aminoglycoside adjuvants and stand-alone agents to combat tuberculosisR01AI090048 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GARNEAU-TSODIKOVA, SYLVIE · 2011 to 2021
$4.4M
Bruker AVANCE NEO 600 MHz High-Performance Digital NMR SpectrometerS10OD028690 · OD · UNIVERSITY OF KENTUCKY · PI GARNEAU-TSODIKOVA, SYLVIE · 2020 to 2020
$1.4M
NIAID NIH HHS R01 AI090048NIH HHS S10 OD028690
6 · The paper itself

Abstract

Tuberculosis (TB), caused by

Identifiers

PMID34825186
PMCPMC8597425
OpenAlexW3204101462

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.