Evidence map›Paper›PMID 34825153›Full record

ArticleJHEP reports : innovation in hepatology2021

Monocyte dysfunction in decompensated cirrhosis is mediated by the prostaglandin E2-EP4 pathway.

Alexander A Maini, Natalia Becares, Louise China, Thais H Tittanegro, Amit Patel, Roel P H De Maeyer, Nekisa Zakeri, Tu Vinh Long, Lucy Ly, Derek W Gilroy and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JHEP reports : innovation in hepatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. [Advances in the diagnosis, treatment, and prognosis of acute decompensatory cirrhosis].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2023
    Review
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Alexander A MainiInstitute of Liver and Digestive Health, University College London, London, UK.
Natalia BecaresInstitute of Liver and Digestive Health, University College London, London, UK.
Louise ChinaInstitute of Liver and Digestive Health, University College London, London, UK.
Thais H TittanegroInstitute of Liver and Digestive Health, University College London, London, UK.
Amit PatelDivision of Medicine, University College London, London, UK.
Roel P H De MaeyerDivision of Medicine, University College London, London, UK.
Nekisa ZakeriInstitute of Liver and Digestive Health, University College London, London, UK.
Tu Vinh LongRoyal Free Hospital NHS Trust, London, UK.
Lucy LyBarts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Derek W GilroyDivision of Medicine, University College London, London, UK.
Alastair O'BrienInstitute of Liver and Digestive Health, University College London, London, UK.
University College London · GBQueen Mary University of London · GBThe Royal Free Hospital · GB

Funding

Medical Research Council MR/M005291/1
6 · The paper itself

Abstract

BACKGROUND &

aimsInfection is a major problem in advanced liver disease secondary to monocyte dysfunction. Elevated prostaglandin (PG)E

methodsUsing samples from 11 outpatients with ascites and 28 patients hospitalised with decompensated cirrhosis, we assayed plasma levels of PGE

resultsWe show that hepatic production of PGE

conclusionsPGE LAY SUMMARY: Patients with decompensated cirrhosis (jaundice, fluid build-up, confusion, and vomiting blood) have high infection rates that lead to high mortality rates. A white blood cell subset, monocytes, function poorly in these patients, which is a key factor underlying their sensitivity to infection. We show that monocyte dysfunction in decompensated cirrhosis is mediated by a lipid hormone in the blood, prostaglandin E

Indexed as

ACLF, acute-on-chronic liver failureAD, acute decompensationCAID, cirrhosis-associated immune dysfunctionCM, classical monocytesCOX, cyclooxygenasecPGES, cytosolic PGE synthaseCRP, C-reactive proteinCyclo-oxygenase 1Decompensated cirrhosisDSS, downstream synthasesEIA, enzyme immune assayFACS, polychromatic flow cytometric analysisHLA-DRHLA DR, human leukocyte antigen – DR isotypeHPGD, 15-hydroxyprostaglandin dehydrogenaseHVs, healthy volunteersIL6LC-MS/MS, liquid chromatography-tandem mass spectrometryLPSLPS, lipopolysaccharideMDMs, monocyte-derived macrophagesMFI, mean fluorescence intensityMicrosomal PGE synthase 1mPGES1, microsomal PGE synthase 1NASH, non-alcoholic steatohepatitisOPD, patients with refractory ascites attending hospital outpatient department for day case paracentesisPGE2, prostaglandin E2qPCR, quantitative PCRsCD14, soluble CD14TIPS, transjugular intrahepatic portosystemic shunt insertionTNFTNFα, tumour necrosis factor alpha

Identifiers

PMID34825153
PMCPMC8603213
OpenAlexW3191338970

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.