Evidence map›Paper›PMID 34825152›Full record

ArticleEClinicalMedicine2021

Association of chronic musculoskeletal pain with mortality among UK adults: A population-based cohort study with mediation analysis.

Lingxiao Chen, Manuela L Ferreira, Natasha Nassar, David B Preen, John L Hopper, Shuai Li, Minh Bui, Paula R Beckenkamp, Baoyi Shi, Nigel K Arden and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EClinicalMedicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 3 countries.

Lingxiao ChenFaculty of Medicine and Health, Institute of Bone and Joint Research, The Kolling Institute, Northern Clinical School, University of Sydney, Sydney, NSW 2064, Australia.
Manuela L FerreiraFaculty of Medicine and Health, Institute of Bone and Joint Research, The Kolling Institute, Northern Clinical School, University of Sydney, Sydney, NSW 2064, Australia.
Natasha NassarFaculty of Medicine and Health, Children's Hospital Westmead Clinical School, University of Sydney, Sydney, Australia.
David B PreenSchool of Population and Global Health, The University of Western Australia, Perth, Australia.
John L HopperCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Australia.
Shuai LiCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Australia.
Minh BuiCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Australia.
Paula R BeckenkampSchool of Health Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, Australia.
Baoyi ShiDepartment of Biostatistics, Mailman School of Public Health, Columbia University, NY, United States.
Nigel K ArdenNuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom.
Paulo H FerreiraSchool of Health Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, Australia.
The University of Sydney · AUThe University of Melbourne · AUColumbia University · USNuffield Orthopaedic Centre · GBThe University of Western Australia · AU

Funding

Medical Research Council MC_PC_17228Medical Research Council MC_QA137853
6 · The paper itself

Abstract

backgroundWe aimed to quantify the association between chronic musculoskeletal pain and all-cause mortality, and to investigate the extent to which this association is mediated by physical activity, smoking status, alcohol consumption, and opioid use.

methodsFor this population-based cohort study, we used data from UK Biobank, UK between baseline visit (2006-2010) to 18th December 2020. We assessed the associations between chronic musculoskeletal pain and all-cause mortality using a Cox proportional hazards model. We performed causal mediation analyses to examine the proportion of the association between chronic musculoskeletal pain and all-cause mortality.

findingsOf the 384,367 included participants, a total of 187,269 participants reported chronic musculoskeletal pain. Higher number of pain sites was associated with increased risk of all-cause mortality compared to having no pain (e.g., four sites vs no site of pain, Hazard Ratio [HR] 1.46, 95% Confidence Interval [CI] 1.35 to 1.57). The multiple mediator analyses showed that the mediating proportions of all four mediators ranged from 53.4% to 122.6%: among participants with two or more pain sites, the effect estimate reduced substantially, for example, HR reduced from 1.25 (95% CI: 1.21 to 1.30; two pain sites) to 1.07 (95% CI: 1.01 to 1.11; two pain sites).

interpretationWe found that higher number of pain sites was associated with increased risk of all-cause mortality compared to having no pain, and at least half of the association of chronic musculoskeletal pain with increased all-cause mortality may be accounted for by four mediators.

fundingTwins Research Australia.

Identifiers

PMID34825152
PMCPMC8605211
OpenAlexW3211661851

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.