Evidence map›Paper›PMID 34825149›Full record

ArticleEClinicalMedicine2021

Associations between biomarkers of environmental enteric dysfunction and oral rotavirus vaccine immunogenicity in rural Zimbabwean infants.

James A Church, Sandra Rukobo, Margaret Govha, Ethan K Gough, Bernard Chasekwa, Benjamin Lee, Marya P Carmolli, Gordana Panic, Natasa Giallourou, Robert Ntozini and 9 more

2 registry-linked trialsOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EClinicalMedicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01824940 nacompletednot on this map

Sanitation, Hygiene, Infant Nutrition Efficacy Project

TypeinterventionalSponsorJohns Hopkins Bloomberg School of Public HealthRan2012 to 2017Enrolled5,280ConditionsGrowth, Stunting, Nutritional, AnemiaArmsStandard care, WASH, Infant and young child feeding, WASH and Nutrition
NCT07626606 recruitingnot on this mapstarted 2026, after this paper: background citation

Temporal and Spatial Immune Profiling of Oral Rotavirus Vaccine Responses in Zambian Adults With Environmental Enteropathy

TypeobservationalSponsorCentre for Infectious Disease Research in ZambiaRan2026 to 2026Enrolled43ConditionsFeasibility Study, Vaccine Immune Response, Rota Virus Gastroenteritis, TranscriptomicsArmsRotarix®,
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 6 institutions in 3 countries.

James A ChurchZvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe.
Sandra RukoboZvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe.
Margaret GovhaZvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe.
Ethan K GoughZvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe.
Bernard ChasekwaZvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe.
Benjamin LeeDepartments of Pediatrics, Vaccine Testing Center, Larner College of Medicine, University of Vermont, Burlington, VT, USA.
Marya P CarmolliDepartments of Microbiology and Molecular Genetics, Vaccine Testing Center, Larner College of Medicine, University of Vermont, Burlington, VT, USA.
Gordana PanicFaculty of Medicine, Imperial College London, South Kensington Campus, London SW7 2AZ, UK.
Natasa GiallourouFaculty of Medicine, Imperial College London, South Kensington Campus, London SW7 2AZ, UK.
Robert NtoziniZvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe.
Kuda MutasaZvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe.
Monica M McNealDepartment of Pediatrics, University of Cincinnati College of Medicine, Division of Infectious Diseases, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Florence D MajoZvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe.
Naume V TavengwaZvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe.
Jonathan R SwannFaculty of Medicine, Imperial College London, South Kensington Campus, London SW7 2AZ, UK.
Lawrence H MoultonDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Beth D KirkpatrickDepartments of Microbiology and Molecular Genetics, Vaccine Testing Center, Larner College of Medicine, University of Vermont, Burlington, VT, USA.
Jean H HumphreyZvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe.
Andrew J PrendergastZvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe.
Zvitambo Institute for Maternal and Child Health Research · ZWJohns Hopkins University · USImperial College London · GBUniversity of Vermont · USCincinnati Children's Hospital Medical Center · USQueen Mary University of London · GB

Funding

Using Dengue Controlled Human Infection Model to Identify Adaptive Immune Correlates of ProtectionP20GM125498 · NIGMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI Ellen Kozelka · 2018 to 2026
$24.9M
NIGMS NIH HHS P20 GM125498
6 · The paper itself

Abstract

backgroundOral rotavirus vaccines (RVV) are poorly immunogenic in low-income countries. Environmental enteric dysfunction (EED) resulting from poor water, sanitation and hygiene (WASH) may contribute. We therefore tested associations between EED and RVV immunogenicity, and evaluated the effect of improved WASH on EED.

methodsWe measured nine biomarkers of EED among Zimbabwean infants born to mothers enrolled in a cluster-randomised 2 × 2 factorial trial of improved WASH and improved feeding between November 2012 and March 2015 (NCT01824940). We used multivariable regression to determine associations between EED biomarkers and RVV seroconversion, seropositivity and geometric mean titer. Log-binomial regression was used to evaluate the effect of improved WASH on EED.

findingsAmong 303 infants with EED biomarkers and immunogenicity data, plasma intestinal fatty-acid binding protein and stool myeloperoxidase were positively associated with RVV seroconversion; adjusted RR 1.63 (95%CI 1.04, 2.57) and 1.29 (95%CI 1.01, 1.65), respectively. There were no other associations between RVV immunogenicity and either individual biomarkers or EED domains (intestinal permeability, intestinal damage, intestinal inflammation and microbial translocation). EED biomarkers did not differ between randomised WASH and non-WASH groups.

interpretationWe found no evidence that EED was associated with poor RVV immunogenicity. Contrary to our hypothesis, there was weak evidence that EED was associated with increased seroconversion. EED biomarkers were not affected by a package of household-level WASH interventions.

Indexed as

AfricaEnteropathyEnvironmental enteric dysfunctionInfantsOral vaccineRotavirus

Identifiers

PMID34825149
PMCPMC8605235
OpenAlexW3212064111

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.