Evidence map›Paper›PMID 34825133›Full record

ArticleiScience2021

Genomic and experimental evidence that ALK

Haider Inam, Ivan Sokirniy, Yiyun Rao, Anushka Shah, Farnaz Naeemikia, Edward O'Brien, Cheng Dong, David M McCandlish, Justin R Pritchard

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Deciphering the Mechanistic Basis for Perfluoroalkyl-Protein Interactions.Chembiochem : a European journal of chemical biology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Haider InamDepartment of Biomedical Engineering, 211 Wartik Lab, The Pennsylvania State University, University Park, PA 16802, USA.
Ivan SokirniyThe Huck Institute for the Life Sciences, The Pennsylvania State University, University Park, PA 16802, USA.
Yiyun RaoThe Huck Institute for the Life Sciences, The Pennsylvania State University, University Park, PA 16802, USA.
Anushka ShahDepartment of Biology, The Pennsylvania State University, University Park, PA 16802, USA.
Farnaz NaeemikiaDepartment of Biomedical Engineering, 211 Wartik Lab, The Pennsylvania State University, University Park, PA 16802, USA.
Edward O'BrienDepartment of Chemistry, The Pennsylvania State University, University Park, PA 16802, USA.
Cheng DongDepartment of Biomedical Engineering, 211 Wartik Lab, The Pennsylvania State University, University Park, PA 16802, USA.
David M McCandlishSimons Center for Quantitative Biology, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.
Justin R PritchardDepartment of Biomedical Engineering, 211 Wartik Lab, The Pennsylvania State University, University Park, PA 16802, USA.
Pennsylvania State University · USCold Spring Harbor Laboratory · US

Funding

Translation Kinetics and their Effects on Protein Structure and Function, mRNA half-lives, and Cellular PhenotypeR35GM124818 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI Edward Patrick O'Brien · 2017 to 2026
$4.0M
Computational analysis of complex genetic interactionsR35GM133613 · NIGMS · COLD SPRING HARBOR LABORATORY · PI David Martin McCandlish · 2019 to 2026
$3.5M
Personalization and Failure Testing of Dual Switch Gene Drives in Lung CancerU01CA265709 · NCI · PENNSYLVANIA STATE UNIVERSITY, THE · PI PRITCHARD, JUSTIN · 2021 to 2025
$2.6M
Research Training in Physiological Adaptations to StressT32GM108563 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI CANTORNA, MARGHERITA T, KORZICK, DONNA HOPE · 2014 to 2023
$2.2M
Model Driven Construction of Dual-switch Selection Gene Drives to Combat Drug ResistanceR21EB026617 · NIBIB · PENNSYLVANIA STATE UNIVERSITY, THE · PI PRITCHARD, JUSTIN · 2019 to 2021
$628k
NCI NIH HHS U01 CA265709NIBIB NIH HHS R21 EB026617NIGMS NIH HHS R35 GM124818NIGMS NIH HHS R35 GM133613NIGMS NIH HHS T32 GM108563
6 · The paper itself

Abstract

Genomic data can facilitate personalized treatment decisions by enabling therapeutic hypotheses in individual patients. Mutual exclusivity has been an empirically useful signal for identifying activating mutations that respond to single agent targeted therapies. However, a low mutation frequency can underpower this signal for rare variants. We develop a resampling based method for the direct pairwise comparison of conditional selection between sets of gene pairs. We apply this method to a transcript variant of anaplastic lymphoma kinase (ALK) in melanoma, termed ALK

Indexed as

Biological sciencesCancer systems biologySystems biology

Identifiers

PMID34825133
PMCPMC8603052
OpenAlexW3208585578

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.