Evidence map›Paper›PMID 34825130›Full record

ArticleJournal of translational genetics and genomics2021

Roles of interacting stress-related genes in lifespan regulation: insights for translating experimental findings to humans.

Anatoliy I Yashin, Deqing Wu, Konstantin Arbeev, Arseniy P Yashkin, Igor Akushevich, Olivia Bagley, Matt Duan, Svetlana Ukraintseva

Open access · diamondAbstract read
PubMed Full text at PMC
In one paragraph

Article in Journal of translational genetics and genomics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 60% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Anatoliy I YashinBiodemography of Aging Research Unit, Duke University, Durham, NC 27705, USA.
Deqing WuBiodemography of Aging Research Unit, Duke University, Durham, NC 27705, USA.
Konstantin ArbeevBiodemography of Aging Research Unit, Duke University, Durham, NC 27705, USA.
Arseniy P YashkinBiodemography of Aging Research Unit, Duke University, Durham, NC 27705, USA.
Igor AkushevichBiodemography of Aging Research Unit, Duke University, Durham, NC 27705, USA.
Olivia BagleyBiodemography of Aging Research Unit, Duke University, Durham, NC 27705, USA.
Matt DuanBiodemography of Aging Research Unit, Duke University, Durham, NC 27705, USA.
Svetlana UkraintsevaBiodemography of Aging Research Unit, Duke University, Durham, NC 27705, USA.
Social Science Research Council · US

Funding

HRS Yrs29-34: Y33 SSA CoFundingU01AG009740 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Jessica Faul, KENNETH M LANGA · 1990 to 2026
$555.8M
Creating a National Resource for Genetic Research in Behavioral & Health SciencesRC2AG036495 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WEIR, DAVID R. · 2009 to 2010
$7.4M
Expanding a National Resource for Genetic Research in Behavioral & Health ScienceRC4AG039029 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WEIR, DAVID R. · 2010 to 2010
$6.0M
Racial and Geographic Disparities in Risk and Survival of Alzheimer's Disease and Related DementiasR01AG066133 · NIA · DUKE UNIVERSITY · PI AKUSHEVICH, IGOR · 2019 to 2023
$3.7M
Understanding Alzheimer's Disease in the Context of the AgingR01AG062623 · NIA · DUKE UNIVERSITY · PI OUKRAINTSEVA, SVETLANA V. · 2019 to 2023
$3.6M
Genetics of changes in population pyramids: Implications for health forecasting with a focus on Alzheimer's Disease and related dementiasRF1AG046860 · NIA · DUKE UNIVERSITY · PI YASHIN, ANATOLIY I · 2019 to 2019
$3.1M
NIA NIH HHS R01 AG062623NIA NIH HHS R01 AG066133NIA NIH HHS RC2 AG036495NIA NIH HHS RC4 AG039029NIA NIH HHS RF1 AG046860NIA NIH HHS U01 AG009740
6 · The paper itself

Abstract

aimExperimental studies provided numerous evidence that caloric/dietary restriction may improve health and increase the lifespan of laboratory animals, and that the interplay among molecules that sense cellular stress signals and those regulating cell survival can play a crucial role in cell response to nutritional stressors. However, it is unclear whether the interplay among corresponding genes also plays a role in human health and lifespan.

methodsLiterature about roles of cellular stressors have been reviewed, such as amino acid deprivation, and the integrated stress response (ISR) pathway in health and aging. Single nucleotide polymorphisms (SNPs) in two candidate genes (

resultsSignificant interactions have been found between SNPs from

conclusionIdentifying associations of the genetic interactions with human survival is an important step in translating the knowledge from experimental to human aging research. Significant associations of multiple SNPxSNP interactions in ISR genes with survival to the oldest old age that have been found in this study, can help uncover mechanisms of multifactorial regulation of human lifespan and its heterogeneity.

Indexed as

amino acids starvationGCN2/EIF2AK4 and CHOP/DDI3T genesGxG interactionshealth and lifespanIntegrated stress response

Identifiers

PMID34825130
PMCPMC8612394
OpenAlexW3200528881

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.