Evidence map›Paper›PMID 34825116›Full record

ReviewCell surface (Amsterdam, Netherlands)2021

Fungal cell wall components modulate our immune system.

Benoit Briard, Thierry Fontaine, Thirumala-Devi Kanneganti, Neil A R Gow, Nicolas Papon

Erratum issuedAbstract readReview
In one paragraph

Review in Cell surface (Amsterdam, Netherlands), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed.

  1. Review
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  3. Microorganisms · 2026
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Benoit BriardINSERM, Centre d'Etude des Pathologies Respiratoires (CEPR), UMR 1100, Université de Tours, Faculté de Médecine de Tours, Tours, France.
Thierry FontaineUnité de Biologie et Pathogénicité Fongiques, Institut Pasteur, Paris, France.
Thirumala-Devi KannegantiDepartment of Immunology, St Jude Children's Research Hospital, Memphis, TN, USA.
Neil A R GowThe Aberdeen Fungal Group, School of Medicine, Medical Sciences & Nutrition, Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK.
Nicolas PaponUniv Angers, Univ Brest, GEIHP, SFR ICAT, F-49000 Angers, France.

Funding

Medical Research Council MR/N006364/2Medical Research Council MR/V033417/1
6 · The paper itself

Abstract

Invasive fungal infections remain highly problematic for human health. Collectively, they account for more than 1 million deaths a year in addition to more than 100 million mucosal infections and 1 billion skin infections. To be able to make progress it is important to understand the pathobiology of fungal interactions with the immune system. Here, we highlight new advancements pointing out the pivotal role of fungal cell wall components (β-glucan, mannan, galactosaminogalactan and melanin) in modulating host immunity and discuss how these open new opportunities for the development of immunomodulatory strategies to combat deadly fungal infectious diseases.

Indexed as

Cell deathCell wallImmunometabolismInflammasomeInnate immunityMelaninPANoptosisPolysaccharidesPyroptosisTrained immunity

Identifiers

PMID34825116
PMCPMC8603304

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.