Evidence map›Paper›PMID 34825099›Full record

ArticleInternational journal of bioprinting2021

3D Bioprinting of Biomimetic Bilayered Scaffold Consisting of Decellularized Extracellular Matrix and Silk Fibroin for Osteochondral Repair.

Xiao Zhang, Yang Liu, Qiang Zuo, Qingyun Wang, Zuxi Li, Kai Yan, Tao Yuan, Yi Zhang, Kai Shen, Rui Xie and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of bioprinting, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Critical Systematic Review of 3D Bioprinting in Biomedicine.International journal of molecular sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Xiao ZhangDepartment of Orthopedics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Yang LiuDepartment of Orthopedics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Qiang ZuoDepartment of Orthopedics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Qingyun WangDepartment of Orthopedics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Zuxi LiDepartment of Orthopedics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Kai YanDepartment of Orthopedics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Tao YuanDepartment of Orthopedics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Yi ZhangDepartment of Orthopedics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Kai ShenDepartment of Orthopedics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Rui XieDepartment of Orthopedics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Weimin FanDepartment of Orthopedics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recently, three-dimensional (3D) bioprinting technology is becoming an appealing approach for osteochondral repair. However, it is challenging to develop a bilayered scaffold with anisotropic structural properties to mimic a native osteochondral tissue. Herein, we developed a bioink consisting of decellularized extracellular matrix and silk fibroin to print the bilayered scaffold. The bilayered scaffold mimics the natural osteochondral tissue by controlling the composition, mechanical properties, and growth factor release in each layer of the scaffold. The

Indexed as

Extracellular matrixOsteochondral repairPolycaprolactoneSilk fibroinThree-dimensional bioprintingTissue engineering

Identifiers

PMID34825099
PMCPMC8611412

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.