Evidence map›Paper›PMID 34825021›Full record

ArticleData in brief2021

Plasma proteomic data in bipolar II disorders and major depressive disorders.

Hyunju Lee, Sang Jin Rhee, Jayoun Kim, Yunna Lee, Hyeyoung Kim, Junhee Lee, Kangeun Lee, Hyunsuk Shin, Hyeyoon Kim, Tae Young Lee and 7 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Data in brief, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07673913 (Relationship Between Response to Transcranial Magnetic Stimulation and Peripheral Inflammatory and Neuroprotective Biomarkers in Patients With Treatment-Resistant Depression), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07673913 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Relationship Between Response to Transcranial Magnetic Stimulation and Peripheral Inflammatory and Neuroprotective Biomarkers in Patients With Treatment-Resistant Depression

TypeinterventionalSponsorGulhane Training and Research HospitalRan2026 to 2027Enrolled100ConditionsTreatment-resistant Depression (TRD), Major DepressionArmsIntermittent Theta Burst Stimulation (iTBS)
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 4 institutions in 3 countries.

Hyunju LeeDepartment of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea.
Sang Jin RheeDepartment of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea.
Jayoun KimMedical Research Collaborating Center, Seoul National University Hospital, Seoul, Republic of Korea.
Yunna LeeDepartment of Neuropsychiatry, Kosin University Gospel Hospital, Busan, Republic of Korea.
Hyeyoung KimDepartment of Psychiatry, Inha University Hospital, Incheon, Republic of Korea.
Junhee LeeDepartment of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea.
Kangeun LeeDepartment of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea.
Hyunsuk ShinProteomics Core Facility, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea.
Hyeyoon KimProteomics Core Facility, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea.
Tae Young LeeDepartment of Neuropsychiatry, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea.
Minah KimDepartment of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea.
Eun Young KimMental Health Center, Seoul National University Health Care Center. Department of Human Systems Medicine, Seoul National University College of Medicine.
Se Hyun KimDepartment of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea.
Yong Min AhnDepartment of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea.
Jun Soo KwonDepartment of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea.
Dohyun HanProteomics Core Facility, Biomedical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea.
Kyooseob HaDepartment of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea.
Seoul National University · KRSeoul National University Hospital · KRKosin University Gospel Hospital · KRPusan National University Yangsan Hospital · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The proteomics data included in this article supplement the research article titled "Predictive protein markers for the severity of depression in mood disorders: A preliminary trans-diagnostic approach study (manuscript ID: JPSYCHIATRES-D-20-00437)." Plasma protein was analyzed using liquid chromatography-tandem mass spectrometry (LC-MS/MS). This data article included 370 plasma protein profiles expressed in patients with bipolar II disorder (BD-II) and major depressive disorder (MDD). The tables present the comparison of protein expressions between BD-II and MDD, and the relationship between the severity of the depressive symptoms and protein expression. In addition, details of results adjusting the use of each psychotropic medication (antipsychotics, mood stabilizers, and antidepressants) for 20 proteins that showed a significant relationship with the severity of the depressive symptom were presented in the table. Results of the bioinformatics analysis of proteins, which were significantly related to the severity of depressive symptom, are presented. The blood protein profiles and the results of the analyses presented in this data article provide detailed information on the proteins associated with mood disorders, and could be used as the basis for further mass spectrometry studies in psychiatric disorders.

Indexed as

Bipolar II disorderLiquid chromatography-tandem mass spectrometry (LC-MS)Major depressive disorderProteomicsSymptom severity

Identifiers

PMID34825021
PMCPMC8605259
OpenAlexW3205820735

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.