Evidence map›Paper›PMID 34824651›Full record

ArticleCanadian respiratory journal2021

The Extent of Honeycombing on Computed Tomography Cannot Predict the Treatment Outcome of Patients with Acute Exacerbations of Interstitial Lung Disease.

Yurika Nishikawa, Yu Hara, Yoichi Tagami, Ryo Nagasawa, Kota Murohashi, Ayako Aoki, Katsushi Tanaka, Keisuke Watanabe, Nobuyuki Horita, Nobuaki Kobayashi and 3 more

Abstract read
In one paragraph

Article in Canadian respiratory journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Acute exacerbation in fibrotic interstitial lung disease: an international working group report.American journal of respiratory and critical care medicine · 2026
    Review
  2. Observational
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yurika NishikawaDepartment of Pulmonology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Yu HaraDepartment of Pulmonology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.ORCID 0000-0002-2574-2516
Yoichi TagamiDepartment of Pulmonology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Ryo NagasawaDepartment of Pulmonology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Kota MurohashiDepartment of Pulmonology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Ayako AokiDepartment of Pulmonology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Katsushi TanakaDepartment of Pulmonology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Keisuke WatanabeDepartment of Pulmonology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Nobuyuki HoritaDepartment of Pulmonology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Nobuaki KobayashiDepartment of Pulmonology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.ORCID 0000-0002-7064-320X
Masaki YamamotoRespiratory Disease Center, Yokohama City University Medical Center, Yokohama, Japan.
Makoto KudoRespiratory Disease Center, Yokohama City University Medical Center, Yokohama, Japan.
Takeshi KanekoDepartment of Pulmonology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The purpose of this retrospective study was to clarify whether the presence of honeycombing on computed tomography (CT) can affect the prognosis of patients with acute exacerbations (AEs) of interstitial lung diseases (ILDs). Methods: Clinical parameters including age, sex, Charlson Comorbidity Index Score (CCIS), blood biomarkers, and 3-month mortality were retrospectively compared between the CT honeycombing present and absent groups at the diagnosis of AEs of ILDs. Results: Ninety-five patients who were on corticosteroid pulse therapy were assessed. Though log-rank tests showed that Kaplan-Meier survival curves of the high and low ground-glass opacity (GGO) score groups differed significantly in 3-month mortality in patients with AEs of idiopathic ILDs ( Conclusions: The clinical features of patients with or without honeycombing may differ due to the difference in prognostic factors, but these groups were found to have similar prognoses 3 months after AE onset, and clinicopathological examinations according to these groups are essential.

Indexed as

Lung Diseases, InterstitialHumansPrognosisRetrospective StudiesTomography, X-Ray ComputedTreatment Outcome

Identifiers

PMID34824651
PMCPMC8610694

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.