Evidence map›Paper›PMID 34824586›Full record

ReviewStem cells international2021

Tendon Tissue Repair in Prospective of Drug Delivery, Regenerative Medicines, and Innovative Bioscaffolds.

Muhammad Nadeem Hafeez, Nicola d'Avanzo, Valentina Russo, Luisa Di Marzio, Felisa Cilurzo, Donatella Paolino, Massimo Fresta, Barbara Barboni, Hélder A Santos, Christian Celia

Abstract readReview
In one paragraph

Review in Stem cells international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Peritendinous adhesion: Therapeutic targets and progress of drug therapy.Computational and structural biotechnology journal · 2024
    Review
  5. Article
  6. Review
  7. Review
  8. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Muhammad Nadeem HafeezDepartment of Pharmacy, University of Chieti-Pescara "G. d'Annunzio", Chieti 66100, Italy.
Nicola d'AvanzoDepartment of Pharmacy, University of Chieti-Pescara "G. d'Annunzio", Chieti 66100, Italy.ORCID https://orcid.org/0000-0001-6945-6653
Valentina RussoUnit of Basic and Applied Biosciences, Faculty of Bioscience and Agro-Food and Environmental Technology, University of Teramo, Teramo 64100, Italy.ORCID https://orcid.org/0000-0003-4368-2534
Luisa Di MarzioDepartment of Pharmacy, University of Chieti-Pescara "G. d'Annunzio", Chieti 66100, Italy.ORCID https://orcid.org/0000-0002-2518-7188
Felisa CilurzoDepartment of Pharmacy, University of Chieti-Pescara "G. d'Annunzio", Chieti 66100, Italy.ORCID https://orcid.org/0000-0001-7429-5591
Donatella PaolinoDepartment of Clinical and Experimental Medicine, University of Catanzaro "Magna Græcia", Catanzaro 88100, Italy.ORCID https://orcid.org/0000-0002-5223-9879
Massimo FrestaDepartment of Health Science, University of Catanzaro "Magna Græcia", Catanzaro 88100, Italy.ORCID https://orcid.org/0000-0001-8062-817X
Barbara BarboniUnit of Basic and Applied Biosciences, Faculty of Bioscience and Agro-Food and Environmental Technology, University of Teramo, Teramo 64100, Italy.
Hélder A SantosDrug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki 0001, Finland.ORCID https://orcid.org/0000-0001-7850-6309
Christian CeliaDepartment of Pharmacy, University of Chieti-Pescara "G. d'Annunzio", Chieti 66100, Italy.ORCID https://orcid.org/0000-0002-0590-5429

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The natural healing capacity of the tendon tissue is limited due to the hypovascular and cellular nature of this tissue. So far, several conventional approaches have been tested for tendon repair to accelerate the healing process, but all these approaches have their own advantages and limitations. Regenerative medicine and tissue engineering are interdisciplinary fields that aspire to develop novel medical devices, innovative bioscaffold, and nanomedicine, by combining different cell sources, biodegradable materials, immune modulators, and nanoparticles for tendon tissue repair. Different studies supported the idea that bioscaffolds can provide an alternative for tendon augmentation with an enormous therapeutic potentiality. However, available data are lacking to allow definitive conclusion on the use of bioscaffolds for tendon regeneration and repairing. In this review, we provide an overview of the current basic understanding and material science in the field of bioscaffolds, nanomedicine, and tissue engineering for tendon repair.

Identifiers

PMID34824586
PMCPMC8610661

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.