Evidence map›Paper›PMID 34824573›Full record

ArticleHealth sciences and disease : the journal of medicine and health science2021

[Clinical and laboratory features of recessive Limb Girdle Muscular dystrophies in the Department Neurology of University Hospital of Point G].

Th Coulibaly, A J Ouabo, G Landouré, H O Bah, L Cissé, S H Diallo, S Diallo, O Samassékou, A B Maïga, F Kané and 10 more

Abstract readEnglish Abstract
PubMed Full text at PMC
In one paragraph

Article in Health sciences and disease : the journal of medicine and health science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Th CoulibalyService de Neurologie, Centre Hospitalier Universitaire du Point G, Bamako, Mali.
A J OuaboService de Neurologie, Centre Hospitalier Universitaire du Point G, Bamako, Mali.
G LandouréService de Neurologie, Centre Hospitalier Universitaire du Point G, Bamako, Mali.
H O BahFaculté de Médecine et d'Odontostomatologie, USTTB, Bamako, Mali.
L CisséService de Neurologie, Centre Hospitalier Universitaire du Point G, Bamako, Mali.
S H DialloFaculté de Médecine et d'Odontostomatologie, USTTB, Bamako, Mali.
S DialloService de Neurologie, Centre Hospitalier Universitaire de Gabriel Touré, Bamako, Mali.
O SamassékouFaculté de Médecine et d'Odontostomatologie, USTTB, Bamako, Mali.
A B MaïgaService de Neurologie, Centre Hospitalier Universitaire du Point G, Bamako, Mali.
F KanéFaculté de Médecine et d'Odontostomatologie, USTTB, Bamako, Mali.
A YalcouyéFaculté de Médecine et d'Odontostomatologie, USTTB, Bamako, Mali.
A TamégaFaculté de Médecine et d'Odontostomatologie, USTTB, Bamako, Mali.
A BocoumFaculté de Médecine et d'Odontostomatologie, USTTB, Bamako, Mali.
M E DembéléFaculté de Médecine et d'Odontostomatologie, USTTB, Bamako, Mali.
A TéméService de Neurologie, Centre Hospitalier Universitaire du Point G, Bamako, Mali.
C O SidibéService de Neurologie, Centre Hospitalier Universitaire du Point G, Bamako, Mali.
A K CisséFaculté de Médecine et d'Odontostomatologie, USTTB, Bamako, Mali.
O TraoréFaculté de Médecine et d'Odontostomatologie, USTTB, Bamako, Mali.
M TraoréService de Cytogénétique et de Biologie Reproductive, INSP, Bamako, Mali.
C O GuintoService de Neurologie, Centre Hospitalier Universitaire du Point G, Bamako, Mali.

Funding

Clinical and genetic studies of hereditary neurological disorders in MaliU01HG007044 · NHGRI · UNIV OF SCIENCES, TECH & TECH OF BAMAKO · PI LANDOURE, GUIDA · 2013 to 2022
$3.1M
NHGRI NIH HHS U01 HG007044
6 · The paper itself

Abstract

introductionLimb-Girdle Muscular dystrophies (LGMD) is a group of inherited diseases characterized by predominantly proximal and limb muscle weakness. These are rare diseases that have not been well studied in sub-saharan Africa. The aim of our was the clinical and paraclinical characterization of patients with recessive LGMD at the Department of Neurology of the Teaching Hospital of Point G. PATIENTS AND

methodsWe conducted a longitudinal prospective study which took place from March 2014 to May 2019. Patients with recessive LGMD phenotype were enrolled. Sociodemographic, clinical and laboratory data were analyzed.

resultsWe enrolled 46 families (67 patients), i.e. a frequency of 16.7% among the neurodegenerative diseases seen in the service. Among them, 45.6% came from the Sikasso region. Autosomal recessive inheritance pattern was suspected in 67.4% of the families. Symptoms appeared mainly in the first decade of life. Proximal muscle weakness was found in almost all patients. Cardiac examination showed dilated cardiomyopathy in 4.5% of cases.

conclusionLimb-Girdle muscular dystrophy is a disabling disease that is found in Mali. Further study of these cases could elucidate the underlying genetic defects.

Indexed as

clinicLGMDMaliTeaching Hospital of Point G

Identifiers

PMID34824573
PMCPMC8612446

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.