Evidence map›Paper›PMID 34824397›Full record

ArticleNature biomedical engineering2022

Scalable and modular wireless-network infrastructure for large-scale behavioural neuroscience.

Raza Qazi, Kyle E Parker, Choong Yeon Kim, Ruediger Rill, Makenzie R Norris, Jaeyoon Chung, John Bilbily, Jenny R Kim, Marie C Walicki, Graydon B Gereau and 9 more

Abstract read
In one paragraph

Article in Nature biomedical engineering, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Metaverse technology tree: a holistic view.Frontiers in artificial intelligence · 2025
    Pooled it
  2. Article
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  4. Article
  5. Review
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  14. Adolescent Parvalbumin Expression in the Left Orbitofrontal Cortex Shapes Sociability in Female Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
  15. Review
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  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Raza Qazi *School of Electrical Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea.ORCID http://orcid.org/0000-0002-9491-5783
Kyle E Parker *Department of Anesthesiology, Washington University in St. Louis, St. Louis, MO, USA.ORCID http://orcid.org/0000-0002-5432-6079
Choong Yeon Kim *School of Electrical Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea.ORCID http://orcid.org/0000-0002-0674-7215
Ruediger RillDepartment of Computer Science, University of Colorado Boulder, Boulder, CO, USA.
Makenzie R NorrisDepartment of Anesthesiology, Washington University in St. Louis, St. Louis, MO, USA.
Jaeyoon ChungDepartment of Computer Science, University of Colorado Boulder, Boulder, CO, USA.
John BilbilyDepartment of Anesthesiology, Washington University in St. Louis, St. Louis, MO, USA.
Jenny R KimDepartment of Anesthesiology, Washington University in St. Louis, St. Louis, MO, USA.
Marie C WalickiDepartment of Anesthesiology, Washington University in St. Louis, St. Louis, MO, USA.
Graydon B GereauDepartment of Anesthesiology, Washington University in St. Louis, St. Louis, MO, USA.
Hyoyoung LimDepartment of Computer Science, University of Colorado Boulder, Boulder, CO, USA.
Yanyu XiongDepartment of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Jenna R LeeInterdisciplinary Neuroscience Program, University of Missouri, Columbia, MO, USA.
Melissa A TapiaDepartment of Psychological Sciences, University of Missouri, Columbia, MO, USA.
Alexxai V KravitzDepartment of Psychiatry, Washington University in St. Louis, St. Louis, MO, USA.ORCID http://orcid.org/0000-0001-5983-0218
Matthew J WillDepartment of Psychological Sciences, University of Missouri, Columbia, MO, USA.
Sangtae HaDepartment of Computer Science, University of Colorado Boulder, Boulder, CO, USA. sangtae.ha@colorado.edu.ORCID http://orcid.org/0000-0001-5983-5430
Jordan G McCallDepartment of Anesthesiology, Washington University in St. Louis, St. Louis, MO, USA. jordangmccall@wustl.edu.ORCID http://orcid.org/0000-0001-8295-0664
Jae-Woong JeongSchool of Electrical Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea. jjeong1@kaist.ac.kr.ORCID http://orcid.org/0000-0001-7607-5453

Funding

Stress-induced plasticity in noradrenergic analgesiaR01NS117899 · NINDS · WASHINGTON UNIVERSITY · PI MCCALL, JORDAN G. · 2020 to 2024
$1.9M
Washington University Psychiatry Residency Research Education ProgramR25MH112473 · NIMH · WASHINGTON UNIVERSITY · PI NURI B FARBER, Timothy Eric Spiegel · 2018 to 2026
$1.6M
Dissecting locus coeruleus contributions to stress-induced antinociceptionF31NS124301 · NINDS · WASHINGTON UNIVERSITY · PI NORRIS, MAKENZIE · 2021 to 2022
$68k
NIMH NIH HHS R25 MH112473NINDS NIH HHS F31 NS124301NINDS NIH HHS R01 NS117899
6 · The paper itself

Abstract

The use of rodents to acquire understanding of the function of neural circuits and of the physiological, genetic and developmental underpinnings of behaviour has been constrained by limitations in the scalability, automation and high-throughput operation of implanted wireless neural devices. Here we report scalable and modular hardware and software infrastructure for setting up and operating remotely programmable miniaturized wireless networks leveraging Bluetooth Low Energy for the study of the long-term behaviour of large groups of rodents. The integrated system allows for automated, scheduled and real-time experimentation via the simultaneous and independent use of multiple neural devices and equipment within and across laboratories. By measuring the locomotion, feeding, arousal and social behaviours of groups of mice or rats, we show that the system allows for bidirectional data transfer from readily available hardware, and that it can be used with programmable pharmacological or optogenetic stimulation. Scalable and modular wireless-network infrastructure should facilitate the remote operation of fully automated large-scale and long-term closed-loop experiments for the study of neural circuits and animal behaviour.

Indexed as

NeurosciencesWireless TechnologyAnimalsBehavior, AnimalMiceOptogeneticsProstheses and ImplantsRats

Identifiers

PMID34824397
PMCPMC10180496

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.