ArticleNature ecology & evolution2022
Gene family evolution underlies cell-type diversification in the hypothalamus of teleosts.
Article in Nature ecology & evolution, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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52 citing papers in PubMed, 70 citations in OpenAlex.
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- Cave adaptation drives coordinated transcriptional remodeling across diverse cell types in the brain of a teleost fish.bioRxiv : the preprint server for biology · 2026Article
- Evolution of a central dopamine circuit underlies adaptation of a light-evoked sensorimotor response in the blind cavefish.Science advances · 2026Article
- A comparative brain atlas in the Mexican cavefish identifies widespread changes in cellular composition and gene expression.bioRxiv : the preprint server for biology · 2026Article
- PGE2 modulation of stimulus valence directs zebrafish behavioral fever.bioRxiv : the preprint server for biology · 2026Article
- Gene regulatory co-option drives birdsong neural circuit specialization.bioRxiv : the preprint server for biology · 2026Article
- scBrainScope: cross-species multidimensional brain atlas.Nucleic acids research · 2026Article
- Pth4 neurons define a novel hypothalamic circuit that promotes sleep via brainstem monoaminergic neurons.Current biology : CB · 2026Article
- Pth4 neurons define a novel hypothalamic circuit that promotes sleep via brainstem monoaminergic neurons.bioRxiv : the preprint server for biology · 2025Article
- A Review of Syndromic Forms of Obesity: Genetic Etiology, Clinical Features, and Molecular Diagnosis.Current issues in molecular biology · 2025Review
- The misplaced mouse Pax6 interneuron subclass: A cross-species transcriptomic reassignment.bioRxiv : the preprint server for biology · 2025Article
- A single-cell atlas of the bobtail squid visual and nervous system highlights molecular principles of convergent evolution.Nature ecology & evolution · 2025Article
- Divergence in neuronal signaling pathways despite conserved neuronal identity among Caenorhabditis species.Current biology : CB · 2025Article
- Lineage-resolved analysis of embryonic gene expression evolution inScience (New York, N.Y.) · 2025Article
- Comparative transcriptomic insights into the evolution of vertebrate photoreceptor types.Current biology : CB · 2025Article
- High-resolution comparative single-cell transcriptomics ofbioRxiv : the preprint server for biology · 2025Article
- Cell Type Resolved Expression of Duplicate Genes Retained From Whole Genome Duplication in Atlantic salmon.Genome biology and evolution · 2025Article
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Hundreds of cell types form the vertebrate brain but it is largely unknown how similar cellular repertoires are between or within species or how cell-type diversity evolves. To examine cell-type diversity across and within species, we performed single-cell RNA sequencing of ~130,000 hypothalamic cells from zebrafish (Danio rerio) and surface and cave morphs of Mexican tetra (Astyanax mexicanus). We found that over 75% of cell types were shared between zebrafish and Mexican tetra, which diverged from a common ancestor over 150 million years ago. Shared cell types displayed shifts in paralogue expression that were generated by subfunctionalization after genome duplication. Expression of terminal effector genes, such as neuropeptides, was more conserved than the expression of their associated transcriptional regulators. Species-specific cell types were enriched for the expression of species-specific genes and characterized by the neofunctionalization of expression patterns of members of recently expanded or contracted gene families. Comparisons between surface and cave morphs revealed differences in immune repertoires and transcriptional changes in neuropeptidergic cell types associated with genomic differences. The single-cell atlases presented here are a powerful resource to explore hypothalamic cell types and reveal how gene family evolution and shifts in paralogue expression contribute to cellular diversity.
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