ArticleScientific reports2021
Resting-state functional heterogeneity of the right insula contributes to pain sensitivity.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 17 citations in OpenAlex.
- Patterns of shared and differential neural activity in misophonia and non-misophonic clinical emotional dysregulation.BMC psychiatry · 2026Article
- Acute effects of nitrous oxide on visual processing: a connectome study in healthy adults.Research square · 2026Article
- Intrinsic functional and structural network organization in the macaque insula.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Somatotopic disruption of the functional connectivity of the primary sensorimotor cortex in complex regional pain syndrome type 1.Human brain mapping · 2023Article
- Decreased Functional Connectivity of the Core Pain Matrix in Herpes Zoster and Postherpetic Neuralgia Patients.Brain sciences · 2023Article
- Insula-cingulate structural and functional connectivity: an ultra-high field MRI study.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Revealing the Central Mechanism of Acupuncture for Primary Dysmenorrhea Based on Neuroimaging: A Narrative Review.Pain research & management · 2023Review
- The human insula processes both modality-independent and pain-selective learning signals.PLoS biology · 2022Article
- Supraspinal Mechanisms Underlying Ocular Pain.Frontiers in medicine · 2021Review
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Authors and funding
14 authors at 3 institutions in 2 countries.
Funding
Abstract
Previous studies have described the structure and function of the insular cortex in terms of spatially continuous gradients. Here we assess how spatial features of insular resting state functional organization correspond to individual pain sensitivity. From a previous multicenter study, we included 107 healthy participants, who underwent resting state functional MRI scans, T1-weighted scans and quantitative sensory testing on the left forearm. Thermal and mechanical pain thresholds were determined. Connectopic mapping, a technique using non-linear representations of functional organization was employed to describe functional connectivity gradients in both insulae. Partial coefficients of determination were calculated between trend surface model parameters summarizing spatial features of gradients, modal and modality-independent pain sensitivity. The dominant connectopy captured the previously reported posteroanterior shift in connectivity profiles. Spatial features of dominant connectopies in the right insula explained significant amounts of variance in thermal (R
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