ArticleNature communications2021
Accelerated discovery of superoxide-dismutase nanozymes via high-throughput computational screening.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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Who cites it
33 citing papers in PubMed.
- Artificial intelligence-guided nanozyme engineering for chronic wound healing: from rational design to precision therapeutics.Bioactive materials · 2027Review
- Fluorescent nanozyme-based biosensors: Classification, catalytic mechanisms, and emerging applications.Mikrochimica acta · 2026Review
- Deciphering the Catalytic Mechanism of Oxidoreductase-Like Nanozymes Along the Reaction Pathway: Activity, Specificity and Sustainability.Advanced materials (Deerfield Beach, Fla.) · 2026Review
- Molecular characterization of superoxide dismutase (SOD) genes for optimizing nitrogen-use efficiency and enhancing crop resilience against drought stress in rice.BMC plant biology · 2026Article
- A multi-objective optimization-driven screening approach for maximizing hydrogen storage capacities in MOFs.Scientific reports · 2026Article
- Antioxidant Nanozymes: From Rational Design to Biomedical Applications.Research (Washington, D.C.) · 2026Review
- Engineered metallic hybrid nanozyme for advanced inflammatory disease therapy.Materials today. Bio · 2025Review
- Paper-Based Electrochemical Device Modified with Palladium: Sensor for the Detection of Serotonin and an Immunosensor for the Detection of SOD1.ACS omega · 2025Article
- Cu/Zn/histidine supramolecular assemblies with optimized Cu catalytic sites as an alternative of superoxide dismutase.Nature communications · 2025Article
- Nanozyme eye drops for retinal barrier penetration and vasculopathy repair.Science advances · 2025Article
- Spatial Coordination Structure-Driven Enzyme-Like Selectivity in Single-Atom Nanozymes.Advanced materials (Deerfield Beach, Fla.) · 2025Review
- Nanomedicine in cardiovascular and cerebrovascular diseases: targeted nanozyme therapies and their clinical potential and current challenges.Journal of nanobiotechnology · 2025Review
- Nanozymes expanding the boundaries of biocatalysis.Nature communications · 2025Review
- Targeting the Electron Transport System for Enhanced Longevity.Biomolecules · 2025Review
- Bioinspired artificial antioxidases for efficient redox homeostasis and maxillofacial bone regeneration.Nature communications · 2025Article
- Nanozyme-Based Strategies against Bone Infection.Research (Washington, D.C.) · 2025Review
- Microenvironmental modulation breaks intrinsic pH limitations of nanozymes to boost their activities.Nature communications · 2024Article
- A bioinspired sulfur-Fe-heme nanozyme with selective peroxidase-like activity for enhanced tumor chemotherapy.Nature communications · 2024Article
- Nanozymes: a bibliometrics review.Journal of nanobiotechnology · 2024Review
- MOF-818 nanoparticles as radical scavengers to improve the aging resistance of silk fabric.Scientific reports · 2024Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The activity of nanomaterials (NMs) in catalytically scavenging superoxide anions mimics that of superoxide dismutase (SOD). Although dozens of NMs have been demonstrated to possess such activity, the underlying principles are unclear, hindering the discovery of NMs as the novel SOD mimics. In this work, we use density functional theory calculations to study the thermodynamics and kinetics of the catalytic processes, and we develop two principles, namely, an energy level principle and an adsorption energy principle, for the activity. The first principle quantitatively describes the role of the intermediate frontier molecular orbital in transferring electrons for catalysis. The second one quantitatively describes the competition between the desired catalytic reaction and undesired side reactions. The ability of the principles to predict the SOD-like activities of metal-organic frameworks were verified by experiments. Both principles can be easily implemented in computer programs to computationally screen NMs with the intrinsic SOD-like activity.
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Registered trials
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