ArticleFood chemistry2022
Diversity in blueberry genotypes and developmental stages enables discrepancy in the bioactive compounds, metabolites, and cytotoxicity.
Article in Food chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Genome-wide analysis of MYB and F3'5'H gene families in Vaccinium bracteatum provides insights into anthocyanin biosynthesis.BMC plant biology · 2026Article
- A comprehensive overview of strategies to improve blueberry fruit quality.Frontiers in plant science · 2026Review
- Molecular mechanism of ethylene signaling response gene VcERF061 to promote anthocyanin synthesis in blueberry (Vaccinium corymbosum).BMC plant biology · 2025Article
- Exogenous Gibberellic Acid (GAInternational journal of molecular sciences · 2025Article
- Simulated Gastrointestinal Digestion and In Vitro Fecal Fermentation of PurifiedFoods (Basel, Switzerland) · 2025Article
- LC-MS/MS metabolomics analysis: Leaf harvesting plus pesticide spraying can further improve the growth quality ofFrontiers in plant science · 2025Article
- Phytochemical and Biological Investigations of Crude Extracts ofPharmaceuticals (Basel, Switzerland) · 2024Article
- Comparative Antioxidant Activity and Untargeted Metabolomic Analyses of Sour Cherry Cultivars Based on Ultra-Performance-Time of Flight-Mass Spectrometry.Plants (Basel, Switzerland) · 2024Article
- Phenolic Compound Profiles, Cytotoxic, Antioxidant, Antimicrobial Potentials and Molecular Docking Studies ofPlants (Basel, Switzerland) · 2024Article
- Untargeted metabolomics and conventional quality characterization of rowanberry pomace ingredients in meatballs.Food chemistry: X · 2023Article
- Engineering the MoSAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Cherries and Blueberries-Based Beverages: Functional Foods with Antidiabetic and Immune Booster Properties.Molecules (Basel, Switzerland) · 2022Review
- Exogenous salicylic acid regulates organic acids metabolism in postharvest blueberry fruit.Frontiers in plant science · 2022Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Eight blueberry cultivars at three developmental stages were investigated for metabolite profiling, antioxidant, and anticancer activities. Cultivars- and developmental stages-variations were determined in total phenolic, flavonoid, DPPH, and FRAP antioxidant assays. The anticancer capacity was equal against A549, HepG2, and Caco-2 cancer cells, whereas the inhibition rate was dose-, incubation period-, cultivar-, and developmental stages-dependent. The untargeted metabolite profiling by UPLC-TOF-MS analysis of two contrast cultivars, 'Vernon' and 'Star', throughout the developmental stages revealed 328 metabolites; the majority of them were amino acids, organic acids, and flavonoids. The multivariate statistical analysis identified five metabolites, including quinic acid, methyl succinic acid, chlorogenic acid, oxoadipic acid, and malic acid, with positively higher correlations with all anticancer activities. This comprehensive database of blueberry metabolites along with anticancer activities could be targeted as natural anticancer potentials. This study would be of great value for food, nutraceutical, and pharmaceutical industries as well as plant biotechnologists.
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