ArticleComputers in biology and medicine2022
Optimization of cardiac resynchronization therapy based on a cardiac electromechanics-perfusion computational model.
Article in Computers in biology and medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- A finite element computational framework coupling four-chamber heart mechanics with the systemic and pulmonary circulations.Research square · 2026Article
- Rapid prediction of cardiac activation in the left ventricle with geometric deep learning: a step towards cardiac resynchronization therapy planning.NPJ digital medicine · 2026Article
- Article
- Connecting developed pressure - Preload relationship in ex-vivo beating heart with cellular sarcomere length - Tension relationship.Journal of biomechanics · 2025Article
- Acute effects of mechanical dyssynchrony on left ventricular function and coronary perfusion.Frontiers in bioengineering and biotechnology · 2025Article
- Personalized computational electro-mechanics simulations to optimize cardiac resynchronization therapy.Biomechanics and modeling in mechanobiology · 2024Article
- Computational Medicine: What Electrophysiologists Should Know to Stay Ahead of the Curve.Current cardiology reports · 2024Review
- Rapid estimation of left ventricular contractility with a physics-informed neural network inverse modeling approach.Artificial intelligence in medicine · 2024Article
- Comparison of Left Ventricular Function Derived from Subject-Specific Inverse Finite Element Modeling Based on 3D ECHO and Magnetic Resonance Images.Bioengineering (Basel, Switzerland) · 2024Article
- Simulation of coronary capillary transit time based on full vascular model of the heart.Computer methods and programs in biomedicine · 2024Article
- An in silico study of the effects of left ventricular assist device on right ventricular function and inter-ventricular interaction.Artificial organs · 2023Article
- Computational analysis of ventricular mechanics in hypertrophic cardiomyopathy patients.Scientific reports · 2023Article
- Mechanism of exercise intolerance in heart diseases predicted by a computer model of myocardial demand-supply feedback system.Computer methods and programs in biomedicine · 2022Article
- Review of cardiac-coronary interaction and insights from mathematical modeling.WIREs mechanisms of diseaseReview
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Authors and funding
5 authors.
Funding
Abstract
Cardiac resynchronization therapy (CRT) is an established treatment for left bundle branch block (LBBB) resulting in mechanical dyssynchrony. Approximately 1/3 of patients with CRT, however, are non-responders. To understand factors affecting CRT response, an electromechanics-perfusion computational model based on animal-specific left ventricular (LV) geometry and coronary vascular networks located in the septum and LV free wall is developed. The model considers contractility-flow and preload-activation time relationships, and is calibrated to simultaneously match the experimental measurements in terms of the LV pressure, volume waveforms and total coronary flow in the left anterior descending and left circumflex territories from 2 swine models under right atrium and right ventricular pacing. The model is then applied to investigate the responses of CRT indexed by peak LV pressure and (dP/dt)
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