ArticleJournal of orthopaedic surgery and research2021
Effects of endplate coverage and intervertebral height change on heterotopic ossification following cervical disc replacement.
Article in Journal of orthopaedic surgery and research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed, 20 citations in OpenAlex.
- Anterior bone loss after anterior cervical discectomy and fusion: influence factors and its impact on surgical outcomes.BMC musculoskeletal disorders · 2025Article
- Utilizing MRI and CT to identify risk factors associated with cage subsidence.European journal of medical research · 2025Article
- Artificial intelligence in predicting postoperative heterotopic ossification following anterior cervical disc replacement.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2024Article
- Does the novel artificial cervical joint complex resolve the conflict between stability and mobility after anterior cervical surgery? a finite element study.Frontiers in bioengineering and biotechnology · 2024Article
- On the suitability of additively manufactured gyroid structures and their potential use as intervertebral disk replacement - a feasibility study.Frontiers in bioengineering and biotechnology · 2024Article
- Biomechanical effects of endplate sagittal coverage change on cervical disc replacement: a finite element analysis.Frontiers in bioengineering and biotechnology · 2024Article
- Finite element analysis of optimized novel additively manufactured non-articulating prostheses for cervical total disc replacement.Frontiers in bioengineering and biotechnology · 2023Article
- Long-term functional and radiological outcomes of cervical disc arthroplasty at a tertiary level spine center in India: A retrospective cohort analysis with minimum 2 years of follow-up.Journal of craniovertebral junction & spineArticle
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
backgroundHeterotopic ossification (HO) is a common complication after cervical disc replacement (CDR). Biomechanical factors including endplate coverage and intervertebral disc height change may be related to HO formation. However, there is a dearth of quantitative analysis for endplate coverage, intervertebral height change and their combined effects on HO.
methodsPatients who underwent single-level or two-level CDR with Prestige-LP were retrospectively reviewed. Clinical outcomes were evaluated through Japanese Orthopaedic Association (JOA) score, Neck Disability Index (NDI) score, and visual analogue scale (VAS) score. Radiological data, including the prosthesis-endplate depth ratio, intervertebral height change, posterior heterotopic ossification (PHO) and angular parameters, were collected. Logistic regression analysis was used to identify the potential risk factors. Receiver operating characteristic curves were plotted and the cut-off values of each potential factors were calculated.
resultsA total of 138 patients with 174 surgical segments were evaluated. Both the prosthesis-endplate depth ratio (P < 0.001) and post-operative disc height change (P < 0.001) were predictive factors for PHO formation. The area under the curve (AUC) of the prosthesis-endplate depth ratio, disc height change and their combined effects represented by the combined parameter (CP) were 0.728, 0.712 and 0.793, respectively. The risk of PHO significantly increased when the prosthesis-endplate depth ratio < 93.77% (P < 0.001, OR = 6.909, 95% CI 3.521-13.557), the intervertebral height change ≥ 1.8 mm (P < 0.001, OR = 5.303, 95% CI 2.592-10.849), or the CP representing the combined effect < 84.88 (P < 0.001, OR = 10.879, 95% CI 5.142-23.019).
conclusionsInadequate endplate coverage and excessive change of intervertebral height are both potential risk factors for the PHO after CDR. Endplate coverage less than 93.8% or intervertebral height change more than 1.8 mm would increase the risk of PHO. The combination of these two factors may exacerbate the non-uniform distribution of stress in the bone-implant interface and promote HO development.
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