Evidence map›Paper›PMID 34823536›Full record

ArticleCardiovascular diabetology2021

Effect of blood lipid variability on mortality in patients with type 2 diabetes: a large single-center cohort study.

Mu-Cyun Wang, Chia-Ing Li, Chiu-Shong Liu, Chih-Hsueh Lin, Shing-Yu Yang, Tsai-Chung Li, Cheng-Chieh Lin

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cardiovascular diabetology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Mu-Cyun WangDepartment of Family Medicine, China Medical University Hospital, No. 2, Yude Rd., North Dist., Taichung, 404332, Taiwan (R.O.C.).
Chia-Ing LiSchool of Medicine, College of Medicine, China Medical University, No.91, Hsueh-Shih Road, North Dist., Taichung, 404333, Taiwan (R.O.C.).
Chiu-Shong LiuDepartment of Family Medicine, China Medical University Hospital, No. 2, Yude Rd., North Dist., Taichung, 404332, Taiwan (R.O.C.).
Chih-Hsueh LinDepartment of Family Medicine, China Medical University Hospital, No. 2, Yude Rd., North Dist., Taichung, 404332, Taiwan (R.O.C.).
Shing-Yu YangDepartment of Public Health, College of Public Health, China Medical University, No. 100, Sec. 1, Jingmao Rd., Beitun Dist., Taichung, 406040, Taiwan (R.O.C.).
Tsai-Chung LiDepartment of Public Health, College of Public Health, China Medical University, No. 100, Sec. 1, Jingmao Rd., Beitun Dist., Taichung, 406040, Taiwan (R.O.C.). tcli@mail.cmu.edu.tw.ORCID 0000-0002-3346-7462
Cheng-Chieh LinDepartment of Family Medicine, China Medical University Hospital, No. 2, Yude Rd., North Dist., Taichung, 404332, Taiwan (R.O.C.). cclin@mail.cmuh.org.tw.
China Medical University · TWAsia University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDyslipidemia is a major cardiovascular risk factor and common in diabetes patients. Most guidelines focus on optimal lipid levels, while variation of lipid profiles is far less discussed. This study aims to investigate the association of visit-to-visit variability in blood lipids with all-cause, cardiovascular, and non-cardiovascular mortality in patients with type 2 diabetes.

methodsWe identified 10,583 type 2 diabetes patients aged ≥ 30 years with follow-up ≥ 3 years and who participated in the Diabetes Care Management Program at a medical center in Taiwan. Variability in lipid profiles within 3 years after entry was calculated using coefficient of variation. Cox proportional hazard models were used to evaluate lipid variability in relation to subsequent mortality.

resultsOver a mean follow-up of 6.4 years, 1838 all-cause deaths (809 cardiovascular deaths) were observed. For each 10% increase in variability in high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and total cholesterol, the hazard ratios (95% confidence intervals) of all-cause mortality were 1.30 (1.22-1.37), 1.05 (1.01-1.09), and 1.10 (1.03-1.16), respectively; those of cardiovascular mortality were 1.27 (1.16-1.39), 1.08 (1.02-1.15), and 1.16 (1.07-1.27), respectively. Each 10% increase in high-density lipoprotein cholesterol variability conveyed 31% greater risk of non-cardiovascular mortality. High variability in total cholesterol and low-density lipoprotein cholesterol increased all-cause mortality in subgroups of nonsmoking, regular exercising, non-dyslipidemia, and more severe status of diabetes at baseline.

conclusionsBlood lipid variability except for triglyceride variability was associated with all-cause and cardiovascular mortality in patients with type 2 diabetes.

Indexed as

AdultAgedBiomarkersCause of DeathCholesterol, HDLCholesterol, LDLDiabetes Mellitus, Type 2DyslipidemiasFemaleHumansLipidsMaleMiddle AgedPrognosisRetrospective StudiesRisk AssessmentBiomarkersCholesterol, HDLCholesterol, LDLLipidsTriglyceridesAll-cause mortalityBlood lipid variabilityCardiovascular mortalityType 2 diabetes

Identifiers

PMID34823536
PMCPMC8620132
OpenAlexW3217637989

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.