ArticleBMC health services research2021
Analysis of the potential inappropriate use of medications in pediatric outpatients in China.
Article in BMC health services research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 20 citations in OpenAlex.
- A Quantitative Review of Un-licensed and Off-label Medicines Use in Children Aged 0-2 Years in the Private Sector in South Africa: Extent, Challenges, and Implications.Current pediatric reviews · 2026Article
- Effects of County Medical Community Central Pharmacy on antibiotic use in primary care: a multicenter quasi-experiment.International journal of clinical pharmacy · 2025Article
- Reform progress and achievements of China's incentive policies for pediatric medicine over the last decade.Frontiers in pharmacology · 2025Article
- Paediatric off-label use of drugs in Gansu, China: a multicentre cross-sectional study.BMJ open · 2024Article
- Barriers and facilitators to guideline for the management of pediatric off-label use of drugs in China: a qualitative descriptive study.BMC health services research · 2024Article
- Efficacy of administrative intervention for neurosurgical patients with off-label use of alprostadil lipid microsphere.Scientific reports · 2022Article
- A tool for screening potentially inappropriate prescribing in Chinese children.Frontiers in pharmacology · 2022Article
- Call for Decision Support for High-Alert Medication Administration Among Pediatric Nurses: Findings From a Large, Multicenter, Cross-Sectional Survey in China.Frontiers in pharmacology · 2022Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe appropriate use of medications is essential in children. Yet, detailed information on how drugs are being prescribed and dispensed to pediatric populations is not documented in China.
aimThe study objective was to analyze the details of medicine use and categorize the types of inappropriate use of medications on children.
methodsA retrospective cross-sectional study was conducted on the prescriptions of pediatric outpatients aged < 18 years from 2019 to 2020 at a major Chinese tertiary academic center. Each age group's demographic and clinical characteristics were collected, and the ratios of inappropriate prescriptions were analyzed.
resultsThe total number of pediatric outpatients was 652,152, and 49.37% (322000) were prescribed medications, in which the most widely used medicines were respiratory, anti-infectives, and Traditional Chinese Medicines (TCMs). The prevalence rate of inappropriate prescriptions reached 20.49%, and in 2019 it was higher (21.71%) than that in 2020 (18.36%). The top three common inappropriate categories were indication-related off-label drug use, improper administration frequency, and overdosing, accounting for 67.93, 17.80 and 11.06% of all inappropriate prescriptions, respectively. The inappropriate prescriptions were more likely seen in patients aged 2-5 years and respiratory medicines.
conclusionsThe study findings indicate that inappropriate drug use in pediatric outpatients is still common, and great attention needs to be paid. More prospective trials are required to identify the effectiveness, safety, and necessity of off-label drug use of medicines in children.
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