Evidence map›Paper›PMID 34822783›Full record

ArticleCell2021

A genetically tractable jellyfish model for systems and evolutionary neuroscience.

Brandon Weissbourd, Tsuyoshi Momose, Aditya Nair, Ann Kennedy, Bridgett Hunt, David J Anderson

Open access · greenAbstract read
In one paragraph

Article in Cell, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
26.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 103 citations in OpenAlex.

  1. Review
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  8. Review
  9. Targeting the cell membrane in established and emerging model organisms.bioRxiv : the preprint server for biology · 2025
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  11. Distributed neural computation and the evolution of the first brains.bioRxiv : the preprint server for biology · 2025
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  13. AnOpen biology · 2025
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  14. Article
  15. An updated and spatially validated somatic single-cell atlas ofbioRxiv : the preprint server for biology · 2025
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Brandon WeissbourdDivision of Biology and Biological Engineering 140-18, California Institute of Technology, Pasadena, CA 91125, USA; Howard Hughes Medical Institute, California Institute of Technology, Pasadena, CA 91125, USA; Tianqiao and Chrissy Chen Institute for Neuroscience, California Institute of Technology, Pasadena, CA 91125, USA. Electronic address: bweissb@gmail.com.
Tsuyoshi MomoseSorbonne Université, CNRS, Laboratoire de Biologie du Développement de Villefranche-sur-Mer (LBDV), 06230 Villefranche-sur-Mer, France.
Aditya NairDivision of Biology and Biological Engineering 140-18, California Institute of Technology, Pasadena, CA 91125, USA; Howard Hughes Medical Institute, California Institute of Technology, Pasadena, CA 91125, USA; Tianqiao and Chrissy Chen Institute for Neuroscience, California Institute of Technology, Pasadena, CA 91125, USA.
Ann KennedyDivision of Biology and Biological Engineering 140-18, California Institute of Technology, Pasadena, CA 91125, USA; Howard Hughes Medical Institute, California Institute of Technology, Pasadena, CA 91125, USA; Tianqiao and Chrissy Chen Institute for Neuroscience, California Institute of Technology, Pasadena, CA 91125, USA.
Bridgett HuntDivision of Biology and Biological Engineering 140-18, California Institute of Technology, Pasadena, CA 91125, USA; Howard Hughes Medical Institute, California Institute of Technology, Pasadena, CA 91125, USA; Tianqiao and Chrissy Chen Institute for Neuroscience, California Institute of Technology, Pasadena, CA 91125, USA.
David J AndersonDivision of Biology and Biological Engineering 140-18, California Institute of Technology, Pasadena, CA 91125, USA; Howard Hughes Medical Institute, California Institute of Technology, Pasadena, CA 91125, USA; Tianqiao and Chrissy Chen Institute for Neuroscience, California Institute of Technology, Pasadena, CA 91125, USA. Electronic address: wuwei@caltech.edu.
California Institute of Technology · USCentre National de la Recherche Scientifique · FR

Funding

Generation of novel cell type specific mouse genetic toolsU19MH114830 · NIMH · ALLEN INSTITUTE · PI ZENG, HONGKUI · 2017 to 2021
$64.7M
Multimodal, integrated analysis of neural activity and naturalistic social behavior in freely moving miceR01MH123612 · NIMH · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI ANDERSON, DAVID J, PERONA, PIETRO · 2020 to 2024
$2.1M
A new animal model to examine nervous system function, development, and regenerationK99NS119749 · NINDS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI WEISSBOURD, BRANDON · 2021 to 2022
$251k
Modeling a neural circuit for flexible control of innate behaviorsK99MH117264 · NIMH · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI KENNEDY, ANN KATHRYN · 2019 to 2020
$222k
NIMH NIH HHS K99 MH117264NIMH NIH HHS R01 MH123612NIMH NIH HHS U19 MH114830NINDS NIH HHS K99 NS119749
6 · The paper itself

Abstract

Jellyfish are radially symmetric organisms without a brain that arose more than 500 million years ago. They achieve organismal behaviors through coordinated interactions between autonomously functioning body parts. Jellyfish neurons have been studied electrophysiologically, but not at the systems level. We introduce Clytia hemisphaerica as a transparent, genetically tractable jellyfish model for systems and evolutionary neuroscience. We generate stable F

Indexed as

Biological EvolutionModels, AnimalNeurosciencesAnimalsAnimals, Genetically ModifiedBehavior, AnimalFeeding BehaviorGene TargetingHydrozoaModels, BiologicalNerve NetNeuronsNeuropeptidesarginylphenylalaninamideNeuropeptidesbehaviorClytiacnidarianGCaMPimagingjellyfishnerve netneuropeptideneurosciencetransgenesis

Identifiers

PMID34822783
PMCPMC8629132
OpenAlexW3215300077

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.