Evidence map›Paper›PMID 34822773›Full record

ArticleStem cell reports2021

Rescuing human fetal tissue research in the United States: A call for additional regulatory reform.

Katherine E MacDuffie, Insoo Hyun, Michaela M Krogen, Jennifer C Dempsey, Charles E Murry, Andrew J Copp, Ian A Glass, Dan Doherty

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Modeling Human Gonad Development in Organoids.Tissue engineering and regenerative medicine · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Katherine E MacDuffieDepartment of Speech and Hearing Sciences, University of Washington, Seattle, WA, USA; Treuman Katz Center for Pediatric Bioethics, Seattle Children's Research Institute, Seattle, WA, USA.
Insoo HyunDepartment of Bioethics, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Michaela M KrogenSchool of Public Health, University of Illinois at Chicago, Chicago, IL, USA.
Jennifer C DempseyDepartment of Pediatrics, University of Washington, Seattle, WA, USA.
Charles E MurryInstitute for Stem Cell and Regenerative Medicine, Center for Cardiovascular Biology, Departments of Laboratory Medicine & Pathology, Bioengineering, and Medicine/Cardiology, University of Washington, Seattle, WA, USA; Sana Biotechnology, Seattle, WA, USA.
Andrew J CoppDevelopmental Biology and Cancer Department, Great Ormond Street Institute of Child Health, University College London, London, UK.
Ian A GlassDepartment of Pediatrics, University of Washington, Seattle, WA, USA; Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA, USA.
Dan DohertyDepartment of Pediatrics, University of Washington, Seattle, WA, USA; Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA, USA. Electronic address: ddoher@uw.edu.

Funding

Mechanisms of Brain Dysmorphology in MN1 C-Terminal Truncation Syndrome, a Novel Intellectual Developmental Disability Disorder P50HD103524 · NICHD · UNIVERSITY OF WASHINGTON · PI Sandra E Juul · 2020 to 2026
$9.9M
The experience of human subjects with brain organoid researchK99MH125328 · NIMH · UNIVERSITY OF WASHINGTON · PI MACDUFFIE, KATE E. · 2020 to 2021
$265k
NICHD NIH HHS P50 HD103524NIMH NIH HHS K99 MH125328
6 · The paper itself

Abstract

Research using human fetal tissue has saved millions of lives through vaccines and other advances, but was markedly restricted by federal regulations in 2019. Although the restrictions were partially reversed in 2021, additional regulatory changes are needed to prevent further damage to essential research programs while preserving protection for human subjects.

Indexed as

Social Control, FormalAdultAgedFemaleFetal ResearchGovernmentHumansMaleMiddle AgedNational Institutes of Health (U.S.)Research Support as TopicSelf ReportUnited States

Identifiers

PMID34822773
PMCPMC8693650

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.