Evidence map›Paper›PMID 34822771›Full record

ArticleStem cell reports2021

Cell autonomous TGFβ signaling is essential for stem/progenitor cell recruitment into degenerative tendons.

Guak-Kim Tan, Brian A Pryce, Anna Stabio, Douglas R Keene, Sara F Tufa, Ronen Schweitzer

Abstract read
In one paragraph

Article in Stem cell reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Lack of skeletal muscle contraction disrupts fibrous tissue morphogenesis in the developing murine knee.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2023
    Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Guak-Kim TanResearch Division, Shriners Hospital for Children, Portland, OR 97239, USA; Department of Orthopaedics and Rehabilitation, School of Medicine, Oregon Health & Science University, Portland, OR 97239, USA. Electronic address: tagu@ohsu.edu.
Brian A PryceResearch Division, Shriners Hospital for Children, Portland, OR 97239, USA.
Anna StabioResearch Division, Shriners Hospital for Children, Portland, OR 97239, USA.
Douglas R KeeneResearch Division, Shriners Hospital for Children, Portland, OR 97239, USA.
Sara F TufaResearch Division, Shriners Hospital for Children, Portland, OR 97239, USA.
Ronen SchweitzerResearch Division, Shriners Hospital for Children, Portland, OR 97239, USA; Department of Orthopaedics and Rehabilitation, School of Medicine, Oregon Health & Science University, Portland, OR 97239, USA. Electronic address: schweitz@ohsu.edu.

Funding

Experimental Resources for Studies of Tenocyte Differentiation and Cell Fate DiversityR01AR072716 · NIAMS · OREGON HEALTH & SCIENCE UNIVERSITY · PI SCHWEITZER, RONEN · 2018 to 2022
$1.7M
Transcriptional regulation of tendon differentiation and matrix formationR01AR055973 · NIAMS · OREGON HEALTH & SCIENCE UNIVERSITY · PI SCHWEITZER, RONEN · 2010 to 2014
$1.7M
Maintenance and Regulation of Tendon and Ligament Maturation by TGFbeta SignalingR01AR067211 · NIAMS · OREGON HEALTH & SCIENCE UNIVERSITY · PI SCHWEITZER, RONEN · 2016 to 2020
$1.5M
NIAMS NIH HHS R01 AR055973NIAMS NIH HHS R01 AR067211NIAMS NIH HHS R01 AR072716
6 · The paper itself

Abstract

Understanding cell recruitment in damaged tendons is critical for improvements in regenerative therapy. We recently reported that targeted disruption of transforming growth factor beta (TGFβ) type II receptor in the tendon cell lineage (Tgfbr2

Indexed as

Signal TransductionAnimalsBiomarkersCells, CulturedClone CellsGreen Fluorescent ProteinsIntegrasesMiceModels, BiologicalMutationReceptor, Transforming Growth Factor-beta Type IIStem CellsTendonsTime FactorsTransforming Growth Factor betaBiomarkersCre recombinaseGreen Fluorescent ProteinsIntegrasesReceptor, Transforming Growth Factor-beta Type IITransforming Growth Factor betacell autonomouscell recruitmentScleraxisScxCreSox9stem/progenitor cellstendontendon degenerationTGFβ signalingTGFβ type II receptor

Identifiers

PMID34822771
PMCPMC8693658

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.