ArticleProteomics. Clinical applications2022
Proteomic analysis identified potential age-associated prognostic biomarkers in pneumonia-derived paediatric sepsis.
Article in Proteomics. Clinical applications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Proteomic biomarkers for early diagnosis and prognosis in pediatric sepsis.World journal of clinical pediatrics · 2026Article
- Changes in plasma inflammatory injury factors and their clinical significance in pediatric bacterial pneumonia and sepsis.Open life sciences · 2026Article
- Dynamic alterations and clinical implications of the plasma proteome in pediatric sepsis.European journal of medical research · 2025Article
- Peptidomics characteristics of pediatric sepsis.Scientific reports · 2025Article
- Multilevel omics for the discovery of biomarkers in pediatric sepsis.Pediatric investigation · 2023Review
- Molecular Framework of Mouse Endothelial Cell Dysfunction during Inflammation: A Proteomics Approach.International journal of molecular sciences · 2022Article
- Proteomic analysis identified potential age-associated prognostic biomarkers in pneumonia-derived paediatric sepsis.Proteomics. Clinical applications · 2022Article
- Association of lipid metabolism with pneumonia risk in under-five children in China.Jornal de pediatriaArticle
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Authors and funding
8 authors.
Funding
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Abstract
purposeOur aim was to investigate the age-associated plasma protein profiles in pneumonia-derived sepsis between infants and toddlers and identify potential age-adapted prognostic markers for poor outcome of pneumonia-derived pediatric sepsis. EXPERIMENTAL
designA nested case-control study strategy was applied. The plasma proteomes of pneumonia-derived pediatric septic patients with different outcomes between infants and toddlers were respectively analysed compared to their age-matched controls.
resultsCompared to toddlers, pneumonia-derived sepsis in infants was characterized by increased upregulation of protein processing in the ER, proteasome and antigen processing and presentation; and reduced downregulation in complement and coagulation cascades and cholesterol metabolism. Among them, the pentose phosphate pathway as well as the complement and coagulation cascades were possibly associated with poor outcome of pneumonia-derived sepsis. Furthermore, we confirmed that HP, THBS1, and SAA1/2 were potential prognostic markers for poor outcome of pneumonia-derived sepsis in infant patient groups. CONCLUSIONS AND CLINICAL RELEVANCE: Age-associated plasma protein profiles of pneumonia-derived pediatric septic patients provided potential age-adapted biomarkers for a more precise prognosis of poor outcome in pneumonia-derived pediatric sepsis and helped to improve the survival of septic children.
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