Evidence map›Paper›PMID 34822608›Full record

ArticleToxins2021

The Deleterious Effects of Shiga Toxin Type 2 Are Neutralized In Vitro by FabF8:Stx2 Recombinant Monoclonal Antibody.

Daniela Luz, Fernando D Gómez, Raíssa L Ferreira, Bruna S Melo, Beatriz E C Guth, Wagner Quintilio, Ana Maria Moro, Agostina Presta, Flavia Sacerdoti, Cristina Ibarra and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxins, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Therapeutic Antibodies Against Shiga Toxins: Trends and Perspectives.Frontiers in cellular and infection microbiology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 3 countries.

Daniela LuzLaboratório de Bacteriologia, Instituto Butantan, Sao Paulo 05503-900, Brazil.
Fernando D GómezLaboratorio de Fisiopatogenia, Instituto de Fisiología y Biofísica Bernardo Houssay (IFIBIO Houssay-CONICET), Departamento de Fisiología, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires 1121, Argentina.
Raíssa L FerreiraLaboratório de Bacteriologia, Instituto Butantan, Sao Paulo 05503-900, Brazil.
Bruna S MeloLaboratório de Bacteriologia, Instituto Butantan, Sao Paulo 05503-900, Brazil.
Beatriz E C GuthDepartamento de Microbiologia, Imunologia e Parasitologia, Universidade Federal de Sāo Paulo, Sao Paulo 04023-062, Brazil.ORCID 0000-0003-1689-3213
Wagner QuintilioLaboratório de Biofármacos, Instituto Butantan, Sao Paulo 05503-900, Brazil.ORCID 0000-0002-3382-8184
Ana Maria MoroLaboratório de Biofármacos, Instituto Butantan, Sao Paulo 05503-900, Brazil.ORCID 0000-0002-0650-7764
Agostina PrestaLaboratorio de Fisiopatogenia, Instituto de Fisiología y Biofísica Bernardo Houssay (IFIBIO Houssay-CONICET), Departamento de Fisiología, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires 1121, Argentina.
Flavia SacerdotiLaboratorio de Fisiopatogenia, Instituto de Fisiología y Biofísica Bernardo Houssay (IFIBIO Houssay-CONICET), Departamento de Fisiología, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires 1121, Argentina.
Cristina IbarraLaboratorio de Fisiopatogenia, Instituto de Fisiología y Biofísica Bernardo Houssay (IFIBIO Houssay-CONICET), Departamento de Fisiología, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires 1121, Argentina.
Gang ChenBanting and Best Department of Medical Research, Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, OT M5S 3E1, Canada.
Sachdev S SidhuBanting and Best Department of Medical Research, Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, OT M5S 3E1, Canada.
María Marta AmaralLaboratorio de Fisiopatogenia, Instituto de Fisiología y Biofísica Bernardo Houssay (IFIBIO Houssay-CONICET), Departamento de Fisiología, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires 1121, Argentina.
Roxane M F PiazzaLaboratório de Bacteriologia, Instituto Butantan, Sao Paulo 05503-900, Brazil.ORCID 0000-0003-0068-8506
Instituto Butantan · BRConsejo Nacional de Investigaciones Científicas y Técnicas · ARUniversity of Toronto · CAUniversidade Federal de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hemolytic Uremic Syndrome (HUS) associated with Shiga-toxigenic

Indexed as

AnimalsAntibodies, MonoclonalApoptosisChlorocebus aethiopsDose-Response Relationship, DrugEpithelial CellsHemolytic-Uremic SyndromeHumansImmunoglobulin Fab FragmentsKidney GlomerulusRecombinant ProteinsShiga-Toxigenic Escherichia coliShiga Toxin 1Shiga Toxin 2Vero CellsAntibodies, MonoclonalImmunoglobulin Fab FragmentsRecombinant ProteinsShiga Toxin 1Shiga Toxin 2antibody fragmentmonoclonal antibodySTECStx2

Identifiers

PMID34822608
PMCPMC8621789
OpenAlexW3214760750

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.