Evidence map›Paper›PMID 34822590›Full record

ArticleToxins2021

Associations between Serum Aflatoxin-B1 and Anemia in Pregnant Women: Evidence from Guangxi Zhuang Birth Cohort in China.

Lei Lei, Shun Liu, Ye Ye, Xiaoqiang Qiu, Dongping Huang, Dongxiang Pan, Jiehua Chen, Zhengmin Qian, Stephen Edward McMillin, Michael G Vaughn and 9 more

Open access · goldAbstract read
In one paragraph

Article in Toxins, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Deoxynivalenol andFoods (Basel, Switzerland) · 2025
    Article
  5. Article
  6. Article
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  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 4 institutions in 2 countries.

Lei LeiDepartment of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Nanning 530021, China.
Shun LiuDepartment of Maternal, Child and Adolescent Health, School of Public Health, Guangxi Medical University, Nanning 530021, China.
Ye YeCenter for Disease Control and Prevention, Guangxi Liuzhou Iron & Steel Group Co., Ltd., Liuzhou 545002, China.
Xiaoqiang QiuDepartment of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Nanning 530021, China.ORCID 0000-0001-9881-3664
Dongping HuangDepartment of Sanitary Chemistry, School of Public Health, Guangxi Medical University, Nanning 530021, China.
Dongxiang PanDepartment of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Nanning 530021, China.
Jiehua ChenDepartment of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Nanning 530021, China.
Zhengmin QianDepartment of Epidemiology and Biostatistics, College for Public Health & Social Justice, Saint Louis University, St. Louis, MO 63103, USA.
Stephen Edward McMillinSchool of Social Work, College for Public Health & Social Justice, Saint Louis University, St. Louis, MO 63103, USA.
Michael G VaughnSchool of Social Work, College for Public Health & Social Justice, Saint Louis University, St. Louis, MO 63103, USA.
Xingxi LuoDepartment of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Nanning 530021, China.
Kaili WuDepartment of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Nanning 530021, China.
Suyang XiaoDepartment of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Nanning 530021, China.
Jinxiu LiDepartment of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Nanning 530021, China.
Meiliang LiuDepartment of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Nanning 530021, China.
Yu YangDepartment of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Nanning 530021, China.
Mingshuang LaiDepartment of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Nanning 530021, China.
Guanghui DongDepartment of Environmental and Occupational Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China.ORCID 0000-0002-2578-3369
Xiaoyun ZengDepartment of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Nanning 530021, China.
Guangxi Medical University · CNSaint Louis University · USLiu Zhou Center for Disease Prevention and Control · CNSun Yat-sen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aflatoxin B1 (AFB1) is a common toxic mycotoxin and is detectable in pregnant women. Animal studies have revealed that AFB1 caused the lysis of erythrocytes and a decrease in hemoglobin. We conducted a prospective cohort study in Guangxi, China, in order to evaluate the association between AFB1 exposure and anemia in pregnant women during the entire pregnancy. A total of 616 pregnant women from the Guangxi Zhuang Birth Cohort were included in the study. Serum AFB1-albumin (AFB1-ALB) adduct levels were measured. The effect of AFB1-ALB adducts on hemoglobin (Hb), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), and mean corpuscular hemoglobin concentration (MCHC) were analyzed by using multivariable linear regression. The risks of anemia from AFB1-ALB adduct exposure were assessed by multivariable logistic regression. We found that the AFB1-ALB adduct was significantly associated with a decrease in Hb (β = -4.99, 95%

Indexed as

AdultAflatoxin B1AnemiaAnemia, HypochromicChinaCohort StudiesErythrocyte IndicesFemaleHemoglobinsHumansInfant, NewbornMaternal ExposurePregnancyPregnancy Complications, HematologicPregnancy TrimestersProspective StudiesAflatoxin B1Hemoglobinsaflatoxin B1anemiacohort studyerythrocyte parametershemoglobinpregnant women

Identifiers

PMID34822590
PMCPMC8618761
OpenAlexW3214077973

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.