Evidence map›Paper›PMID 34822507›Full record

ArticleMarine drugs2021

An Alternative Approach towards C-12 Functionalized Scalaranic Sesterterpenoids Synthesis of 17-Oxo-20-norscalaran-12α,19-

Olga Morarescu, Marina Grinco, Veaceslav Kulciţki, Sergiu Shova, Nicon Ungur

Open access · goldAbstract read
In one paragraph

Article in Marine drugs, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Olga MorarescuLaboratory of Chemistry of Natural and Biologically Active Compounds, Institute of Chemistry, 3 Academiei Str., MD 2028 Chişinău, Moldova.
Marina GrincoLaboratory of Chemistry of Natural and Biologically Active Compounds, Institute of Chemistry, 3 Academiei Str., MD 2028 Chişinău, Moldova.
Veaceslav KulciţkiLaboratory of Chemistry of Natural and Biologically Active Compounds, Institute of Chemistry, 3 Academiei Str., MD 2028 Chişinău, Moldova.ORCID 0000-0002-9363-1615
Sergiu ShovaCEEC Institute, Ningbo University of Technology, No. 201, Fenghua Road, Ningbo City 315211, China.ORCID 0000-0002-1222-4373
Nicon UngurLaboratory of Chemistry of Natural and Biologically Active Compounds, Institute of Chemistry, 3 Academiei Str., MD 2028 Chişinău, Moldova.ORCID 0000-0002-7457-4520
Academy of Sciences of Moldova · MDNingbo University of Technology · CN

Funding

National Agency for Research and Development 20.80009.8007.03
6 · The paper itself

Abstract

Scalarane sesterterpenoids emerged as interesting bioactive natural products which were isolated extensively from marine sponges and shell-less mollusks. Some representatives were also reported recently from superior plants. Many scalarane sesterterpenoids displayed a wide spectrum of valuable properties, such as antifeedant, antimicrobial, antifungal, antitubercular, antitumor, anti-HIV properties, cytotoxicity and stimulation of nerve growth factor synthesis, as well as anti-inflammatory activity. Due to their important biological properties, many efforts have been undertaken towards the chemical synthesis of natural scalaranes. The main synthetic challenges are connected to their complex polycyclic framework, chiral centers and different functional groups, in particular the oxygenated functional groups at the C-12 position, which are prerequisites of the biological activity of many investigated scalaranes. The current work addresses this problem and the synthesis of 17-oxo-20-norscalaran-12α,19-

Indexed as

PoriferaAnimalsAquatic OrganismsHumansMolecular StructureSesterterpenesSesterterpenesnatural terpenoidsscalarane sesterterpenoidssynthesisX-ray analysis

Identifiers

PMID34822507
PMCPMC8625711
OpenAlexW3213660360

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.