ReviewMarine drugs2021
Advances in Phenazines over the Past Decade: Review of Their Pharmacological Activities, Mechanisms of Action, Biosynthetic Pathways and Synthetic Strategies.
Review in Marine drugs, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed.
- Graphitic Carbon Nitride (g-CMolecules (Basel, Switzerland) · 2026Review
- Biocatalytic synthesis of alkoxylated phenazine derivatives using methyltransferases.Microbial cell factories · 2026Article
- Article
- Genomic and spectroscopic analysis for antimicrobial metabolite profiling of Microbacterium testaceum endophyte.AMB Express · 2026Article
- Extracellular matrix chemistry tunes bacterial biofilm metabolism and optimizes fitness.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Marine Bacteria as a Source of Antibiotics AgainstMarine drugs · 2026Review
- Pyocyanin reversibly inhibitsFrontiers in pharmacology · 2026Article
- CRISPR/Cas9 Knockout Studies Implicate Phenazine-1-carboxylic Acid, but Not 2-Hydroxy Phenazine, in the Biocontrol Activity ofMicroorganisms · 2025Article
- Microbial phenazines: biosynthesis, structural diversity, evolution, regulation, and biological significance.Microbiology and molecular biology reviews : MMBR · 2025Review
- Pseudomonas spp. and antimicrobial resistance: unlocking new horizons with 1-hydroxyphenazine.Folia microbiologica · 2025Review
- Phenazines contribute to microbiome dynamics by targeting topoisomerase IV.Nature microbiology · 2025Article
- Extracellular matrix chemistry tunes bacterial biofilm metabolism and optimizes fitness.bioRxiv : the preprint server for biology · 2025Article
- Regioselective Synthesis of Fluorescent Alkoxy-Substituted Phenazines andThe Journal of organic chemistry · 2025Article
- CRISPR-driven enhanced hydrocarbon emulsification in an environmental Pseudomonas aeruginosa strain.Microbial cell factories · 2025Article
- A green marriage: the union of theophylline's catalytic activity and healing potential.RSC advances · 2025Review
- The potential of Paraburkholderia species to enhance crop growth.World journal of microbiology & biotechnology · 2025Review
- Aotaphenazine, a rare hydrophenazine, targets topoisomerase II with anticancer efficacy: In silico to in vitro evidence.PloS one · 2025Article
- Dynamic changes and metabolic function of intestinal flora in patients with postoperative pneumonia after lung cancer surgery.PloS one · 2025Article
- A facile and green procedure in preparing dibenzo-chromeno-phenazine-diones using an effectual and recyclable Brønsted acidic ionic liquid.Scientific reports · 2024Article
- Recent Advances in Phenazine Natural Products: Chemical Structures and Biological Activities.Molecules (Basel, Switzerland) · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Phenazines are a large group of nitrogen-containing heterocycles, providing diverse chemical structures and various biological activities. Natural phenazines are mainly isolated from marine and terrestrial microorganisms. So far, more than 100 different natural compounds and over 6000 synthetic derivatives have been found and investigated. Many phenazines show great pharmacological activity in various fields, such as antimicrobial, antiparasitic, neuroprotective, insecticidal, anti-inflammatory and anticancer activity. Researchers continued to investigate these compounds and hope to develop them as medicines. Cimmino et al. published a significant review about anticancer activity of phenazines, containing articles from 2000 to 2011. Here, we mainly summarize articles from 2012 to 2021. According to sources of compounds, phenazines were categorized into natural phenazines and synthetic phenazine derivatives in this review. Their pharmacological activities, mechanisms of action, biosynthetic pathways and synthetic strategies were summarized. These may provide guidance for the investigation on phenazines in the future.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.