Evidence map›Paper›PMID 34822479›Full record

ReviewMarine drugs2021

Marine Sulfated Polysaccharides: Preventive and Therapeutic Effects on Metabolic Syndrome: A Review.

Ying Li, Juan Qin, Yinghui Cheng, Dong Lv, Meng Li, Yanxia Qi, Jing Lan, Qiancheng Zhao, Zhibo Li

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Marine drugs, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.

  1. Pooled it
  2. Polysaccharides fromMolecules (Basel, Switzerland) · 2024
    Pooled it
  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Ying LiCollege of Food Science and Engineering, Dalian Ocean University, Dalian 116023, China.ORCID 0000-0001-7138-7060
Juan QinCollege of Food Science and Engineering, Dalian Ocean University, Dalian 116023, China.
Yinghui ChengCollege of Food Science and Engineering, Dalian Ocean University, Dalian 116023, China.
Dong LvCollege of Food Science and Engineering, Dalian Ocean University, Dalian 116023, China.
Meng LiCollege of Food Science and Engineering, Dalian Ocean University, Dalian 116023, China.
Yanxia QiCollege of Food Science and Engineering, Dalian Ocean University, Dalian 116023, China.
Jing LanDalian Zhenjiu Biological Industry Co., Ltd., Dalian 116023, China.
Qiancheng ZhaoCollege of Food Science and Engineering, Dalian Ocean University, Dalian 116023, China.
Zhibo LiCollege of Food Science and Engineering, Dalian Ocean University, Dalian 116023, China.
Dalian Ocean University · CN

Funding

Dalian Science and Technology Bureau Program 2020RQ116Key Science and Technology Program of Liaoning Province 2020JH1/10200001National Key Research and Development Program of China 2018YFD0901004Science & Technology Innovation Fund of Dalian 2019J12SN61Youth Breeding Project of Liaoning Province QL202007
6 · The paper itself

Abstract

Metabolic syndrome is the pathological basis of cardiovascular and cerebrovascular diseases and type 2 diabetes. With the prevalence of modern lifestyles, the incidence of metabolic syndrome has risen rapidly. In recent years, marine sulfate polysaccharides (MSPs) have shown positive effects in the prevention and treatment of metabolic syndrome, and they mainly come from seaweeds and marine animals. MSPs are rich in sulfate and have stronger biological activity compared with terrestrial polysaccharides. MSPs can alleviate metabolic syndrome by regulating glucose metabolism and lipid metabolism. In addition, MSPs prevent and treat metabolic syndrome by interacting with gut microbiota. MSPs can be degraded by gut microbes to produce metabolites such as short chain fatty acids (SCFAs) and free sulfate and affect the composition of gut microbiota. The difference between MSPs and other polysaccharides lies in the sulfation pattern and sulfate content, therefore, which is very important for anti-metabolic syndrome activity of MSPs. This review summarizes the latest findings on effects of MSPs on metabolic syndrome, mechanisms of MSPs in treatment/prevention of metabolic syndrome, interactions between MSPs and gut microbiota, and the role of sulfate group and sulfation pattern in MSPs activity. However, more clinical trials are needed to confirm the potential preventive and therapeutic effects on human body. It may be a better choice to develop new functional foods containing MSPs for dietary intervention in metabolic syndrome.

Indexed as

Aquatic OrganismsAnimalsDiabetes Mellitus, Type 2Gastrointestinal MicrobiomeMetabolic SyndromePolysaccharidesPolysaccharidesfunctional foodsgut microbiotamarine sulfate polysaccharidesmetabolic syndromesulfate

Identifiers

PMID34822479
PMCPMC8618309
OpenAlexW3208739793

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.