Evidence map›Paper›PMID 34822434›Full record

ArticleMetabolites2021

Hematological, Micro-Rheological, and Metabolic Changes Modulated by Local Ischemic Pre- and Post-Conditioning in Rat Limb Ischemia-Reperfusion.

Csaba Korei, Balazs Szabo, Adam Varga, Barbara Barath, Adam Deak, Erzsebet Vanyolos, Zoltan Hargitai, Ilona Kovacs, Norbert Nemeth, Katalin Peto

Abstract read
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In one paragraph

Article in Metabolites, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Csaba KoreiDepartment of Traumatology and Hand Surgery, Faculty of Medicine, University of Debrecen, Bartok Bela ut 2-26, H-4031 Debrecen, Hungary.ORCID 0000-0001-6327-5018
Balazs SzaboDepartment of Operative Techniques and Surgical Research, Faculty of Medicine, University of Debrecen, Moricz Zsigmond u. 22, H-4002 Debrecen, Hungary.
Adam VargaDepartment of Operative Techniques and Surgical Research, Faculty of Medicine, University of Debrecen, Moricz Zsigmond u. 22, H-4002 Debrecen, Hungary.
Barbara BarathDepartment of Operative Techniques and Surgical Research, Faculty of Medicine, University of Debrecen, Moricz Zsigmond u. 22, H-4002 Debrecen, Hungary.
Adam DeakDepartment of Operative Techniques and Surgical Research, Faculty of Medicine, University of Debrecen, Moricz Zsigmond u. 22, H-4002 Debrecen, Hungary.
Erzsebet VanyolosDepartment of Operative Techniques and Surgical Research, Faculty of Medicine, University of Debrecen, Moricz Zsigmond u. 22, H-4002 Debrecen, Hungary.
Zoltan HargitaiClinical Center, Pathology Unit, Kenezy Campus, University of Debrecen, Bartok Bela ut 2-26, H-4031 Debrecen, Hungary.
Ilona KovacsClinical Center, Pathology Unit, Kenezy Campus, University of Debrecen, Bartok Bela ut 2-26, H-4031 Debrecen, Hungary.
Norbert NemethDepartment of Operative Techniques and Surgical Research, Faculty of Medicine, University of Debrecen, Moricz Zsigmond u. 22, H-4002 Debrecen, Hungary.ORCID 0000-0002-1162-3778
Katalin PetoDepartment of Operative Techniques and Surgical Research, Faculty of Medicine, University of Debrecen, Moricz Zsigmond u. 22, H-4002 Debrecen, Hungary.

Funding

Bridging Fund of the Faculty of Medicine, University of Debrecen 2020National Research, Development and Innovation Office NKFI-1 "OTKA" K-139184
6 · The paper itself

Abstract

In trauma and orthopedic surgery, limb ischemia-reperfusion (I/R) remains a great challenge. The effect of preventive protocols, including surgical conditioning approaches, is still controversial. We aimed to examine the effects of local ischemic pre-conditioning (PreC) and post-conditioning (PostC) on limb I/R. Anesthetized rats were randomized into sham-operated (control), I/R (120-min limb ischemia with tourniquet), PreC, or PostC groups (3 × 10-min tourniquet ischemia, 10-min reperfusion intervals). Blood samples were taken before and just after the ischemia, and on the first postoperative week for testing hematological, micro-rheological (erythrocyte deformability and aggregation), and metabolic parameters. Histological samples were also taken. Erythrocyte count, hemoglobin, and hematocrit values decreased, while after a temporary decrease, platelet count increased in I/R groups. Erythrocyte deformability impairment and aggregation enhancement were seen after ischemia, more obviously in the PreC group, and less in PostC. Blood pH decreased in all I/R groups. The elevation of creatinine and lactate concentration was the largest in PostC group. Histology did not reveal important differences. In conclusion, limb I/R caused micro-rheological impairment with hematological and metabolic changes. Ischemic pre- and post-conditioning had additive changes in various manners. Post-conditioning showed better micro-rheological effects. However, by these parameters it cannot be decided which protocol is better.

Indexed as

hemorheologyischemic post-conditioningischemic pre-conditioninglimb ischemia-reperfusionmetabolites

Identifiers

PMID34822434
PMCPMC8625580

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.