ArticleMetabolites2021
Cord Blood Metabolome and BMI Trajectory from Birth to Adolescence: A Prospective Birth Cohort Study on Early Life Biomarkers of Persistent Obesity.
Article in Metabolites, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 24 citations in OpenAlex.
- Early ascending growth is associated with maternal lipoprotein profile during mid and late pregnancy and in cord blood.International journal of obesity (2005) · 2023Trial
- Metabolites co-correlating with maternal obesity and gestational weight gain and offspring childhood obesity: a prospective birth cohort study.The American journal of clinical nutrition · 2026Article
- A Prospective Birth Cohort Study on the Association Between Cord Blood Acylcarnitine Profile and Childhood Risk of Attention-Deficit/Hyperactivity Disorder and Autism Spectrum Disorder.Journal of the American Academy of Child and Adolescent Psychiatry · 2026Article
- Evaluating neonatal cord serum metabolome in association with adolescent cardiometabolic risk factors.Pediatric research · 2026Article
- Cord Blood Metabolite Profiles and Childhood Cardio-Metabolic Outcomes in a Population-Based Cohort.Annals of nutrition & metabolism · 2025Article
- The influence of hypertensive disorders in pregnancy on neonatal amino acid and acylcarnitine levels.Frontiers in nutrition · 2025Article
- Newborn DNA methylation age differentiates long-term weight trajectories: the Boston Birth Cohort.BMC medicine · 2024Article
- [A prospective cohort study of association between early childhood body mass index trajectories and the risk of overweight].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2024Article
- Early Life Origins of Cardio-Metabolic Outcomes in Boston Birth Cohort: Review of Findings and Future directions.Precision nutrition · 2023Article
- Plasma Insulin Concentration in Newborns and Children and Age at Menarche.Diabetes care · 2023Article
- Defining longitudinal trajectory of body mass index percentile and predicting childhood obesity: methodologies and findings in the Boston Birth Cohort.Precision nutrition · 2023Article
- Umbilical cord DNA methylation is associated with body mass index trajectories from birth to adolescence.EBioMedicine · 2023Article
- Cord Blood Plasma Metabolome-wide Associations With Height From Birth to Adolescence.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2023Article
- Impact of Maternal Weight Gain on the Newborn Metabolome.Metabolites · 2023Article
- The Associations of Maternal Health Characteristics, Newborn Metabolite Concentrations, and Child Body Mass Index among US Children in the ECHO Program.Metabolites · 2023Article
- Associations between cord blood metabolic factors and early-childhood growth and overweight and obesity.Frontiers in endocrinology · 2023Article
- Cord blood metabolites and rapid postnatal growth as multiple mediators in the prenatal propensity to childhood overweight.International journal of obesity (2005) · 2022Article
- Associations of Cord Blood Lipids with Childhood Adiposity at the Age of Three Years: A Prospective Birth Cohort Study.Metabolites · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
There is increasing recognition on the role of early life metabolic programming in childhood obesity. This study sought to investigate whether newborn cord blood metabolome can predict future BMI. It included 946 children in the Boston Birth Cohort, a sample of high-risk yet understudied US urban, low-income, predominantly Black and Hispanic children, who were enrolled at birth and followed prospectively up to age 18 years. A total of 376 metabolites were measured in cord blood plasma. Longitudinal BMI trajectories were defined and categorized into three distinct patterns: early onset overweight and obesity (early-OWO), late onset OWO (late-OWO), and normal weight trajectory (NW). Multinomial logistic regression models were used to identify metabolites individually or as network modules associated with BMI trajectories. Of the 946 children, 388, 254, and 304 were classified as early-OWO, late-OWO, and NW, respectively. Of the seven co-metabolomic network modules defined, two were inversely correlated with early-OWO. Among the 68 metabolites within the two modules, 22 triacylglycerols and diacylglycerols were negatively associated with early-OWO; 5 cholesterol esters were positively associated with early-OWO. In this prospective birth cohort, we demonstrated distinctive longitudinal BMI trajectories and identified multiple cord plasma metabolites in relevant biological pathways that were associated with early-OWO.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.