Evidence map›Paper›PMID 34822304›Full record

ArticleApplied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme2022

Five-year changes in objectively measured cardiorespiratory fitness, physical activity, and sedentary time in mid-to-late adulthood.

Ryan J Dougherty, Sarah R Lose, Julian M Gaitán, Brandon M Mergen, Nathaniel A Chin, Ozioma C Okonkwo, Dane B Cook

Open access · greenAbstract read
In one paragraph

Article in Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 8 citations in OpenAlex.

  1. Rising energetic cost of walking predicts cognitive impairment.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  2. Do cardiovascular disease patients return to pre-lockdown sedentary levels? A prospective cohort study.Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Associations between physical activity and autonomic function during deep breathing test: the Swedish CArdioPulmonary bioImage Study (SCAPIS).Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2023
    Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Ryan J DoughertyDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Sarah R LoseWisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
Julian M GaitánWisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
Brandon M MergenWisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
Nathaniel A ChinWisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
Ozioma C OkonkwoWisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
Dane B CookWilliam S. Middleton Memorial Veterans Hospital, Madison, Wisconsin, USA.
University of Wisconsin–Madison · USWilliam S. Middleton Memorial Veterans Hospital · US

Funding

Wisconsin Alzheimer's Disease Research CenterP30AG062715 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Dorothy Farrar Edwards · 2019 to 2026
$34.5M
Research Training in Age-Related Cognitive DisordersT32AG027668 · NIA · JOHNS HOPKINS UNIVERSITY · PI MARILYN S. ALBERT · 2007 to 2026
$6.3M
Early detection of asymptomatic middle-age adults at risk for ADK23AG045957 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI OKONKWO, OZIOMA C · 2013 to 2017
$884k
Genetic and Lifestyle Determinants of Cognitive Resilience in MidlifeR21AG051858 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI OKONKWO, OZIOMA C · 2016 to 2017
$441k
Longitudinal Assessment of Physical Activity, Cerebral Glucose Metabolism, and Cognitive Function in an At-risk CohortF31AG062009 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI DOUGHERTY, RYAN JAMES · 2018 to 2019
$63k
CSRD VA IK6 CX002369NIA NIH HHS F31 AG062009NIA NIH HHS K23 AG045957NIA NIH HHS P30 AG062715NIA NIH HHS R21 AG051858NIA NIH HHS T32 AG027668
6 · The paper itself

Abstract

This study examined 5-year changes in cardiorespiratory fitness, physical activity, and sedentary time in mid-to-late aged adults. Fifty-seven participants completed baseline and follow-up treadmill exercise tests and physical activity monitoring. We observed a 14% decline in fitness (

Indexed as

Cardiorespiratory FitnessSedentary BehaviorAccelerometryAgedApolipoprotein E4ExerciseExercise TestFemaleHumansMaleMiddle AgedApolipoprotein E4accelerometeraccéléromètreaerobic fitnessapolipoprotein E4apolipoprotéine E4aptitude aérobiecondition physiqueévaluation longitudinaleexercice physiqueexercisefacteur de risquefacteurs liés au mode de vielifestyle factorslongitudinal assessmentphysical fitnessrisk factor

Identifiers

PMID34822304
PMCPMC9169430
OpenAlexW3215321610

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.