Evidence map›Paper›PMID 34822209›Full record

ArticleAngewandte Chemie (International ed. in English)2022

Binding of Natural Peptide Ligands to the Neuropeptide Y

Sarina Rudolf, Kerstin Kaempf, Oanh Vu, Jens Meiler, Annette G Beck-Sickinger, Irene Coin

Open access · hybridAbstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Direct Quantification of Protein-Protein Interactions in Living Bacterial Cells.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  4. Review
  5. Article
  6. Neuropeptide Y Peptide Family and Cancer: Antitumor Therapeutic Strategies.International journal of molecular sciences · 2023
    Review
  7. Genetically encoded crosslinkers to address protein-protein interactions.Protein science : a publication of the Protein Society · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Sarina RudolfInstitute of Biochemistry, Faculty of Life Science, Leipzig University, 04103, Leipzig, Germany.
Kerstin KaempfInstitute of Biochemistry, Faculty of Life Science, Leipzig University, 04103, Leipzig, Germany.
Oanh VuChemistry Department, Vanderbilt University, Nashville, TN, 37212, USA.
Jens MeilerChemistry Department, Vanderbilt University, Nashville, TN, 37212, USA.
Annette G Beck-SickingerInstitute of Biochemistry, Faculty of Life Science, Leipzig University, 04103, Leipzig, Germany.
Irene CoinInstitute of Biochemistry, Faculty of Life Science, Leipzig University, 04103, Leipzig, Germany.ORCID 0000-0002-7722-004X
Leipzig University · DEVanderbilt University · US

Funding

Membrane Protein Structure Elucidation from sparse NMR data (KAMP)R01GM080403 · NIGMS · VANDERBILT UNIVERSITY · PI MEILER, JENS · 2007 to 2019
$3.0M
Structural Determinants of Allosteric Modulation of Brain GPCRsR01DA046138 · NIDA · VANDERBILT UNIVERSITY · PI MEILER, JENS · 2019 to 2023
$2.0M
Cheminformatics of Allosteric mGluR Modulation promotes Therapeutic DevelopmentR01MH090192 · NIMH · VANDERBILT UNIVERSITY · PI MEILER, JENS · 2010 to 2013
$1.5M
Small Molecule Probes to Investigate Structure and Function of Y ReceptorsR01DK097376 · NIDDK · VANDERBILT UNIVERSITY · PI MEILER, JENS, WEAVER, C DAVID · 2013 to 2015
$1.0M
High-Performance Computer Cluster for Biomedical ResearchS10OD023680 · OD · VANDERBILT UNIVERSITY · PI MEILER, JENS · 2017 to 2017
$587k
Hybrid Methods for Prediction and Design of Novel Human Influenza AntibodiesR56AI110750 · NIAID · VANDERBILT UNIVERSITY · PI CROWE, JAMES E, MEILER, JENS · 2014 to 2014
$433k
Novel Schizophrenia Therapeutics By Virtual High-Throughput ScreeningR21MH082254 · NIMH · VANDERBILT UNIVERSITY · PI MEILER, JENS · 2008 to 2009
$364k
NIAID NIH HHS R56 AI110750NIDA NIH HHS DA046138NIDA NIH HHS R01 DA046138NIDDK NIH HHS R01 DK097376NIGMS NIH HHS R01 GM080403NIH HHS S10 OD023680NIMH NIH HHS R01 MH090192NIMH NIH HHS R21 MH082254
6 · The paper itself

Abstract

The binding mode of natural peptide ligands to the Y

Indexed as

Receptors, Neuropeptide YBinding SitesHumansLigandsModels, MolecularPancreatic PolypeptidePeptidesPeptide YYProtein BindingLigandsneuropeptide Y5 receptorPancreatic PolypeptidePeptidesPeptide YYReceptors, Neuropeptide YAla-scandouble-cycle mutagenesisgenetically encoded crosslinkersmolecular modelingneuropeptide Y

Identifiers

PMID34822209
PMCPMC8766924
OpenAlexW3216841060

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.