Evidence map›Paper›PMID 34822185›Full record

ArticleEuropean journal of immunology2022

AIDS patient with severe T cell depletion achieved control but not clearance of SARS-CoV-2 infection.

Michele Spinicci, Alessio Mazzoni, Beatrice Borchi, Lucia Graziani, Marcello Mazzetti, Filippo Bartalesi, Annarita Botta, Marta Tilli, Filippo Pieralli, Marco Coppi and 6 more

Abstract readCase Reports
In one paragraph

Article in European journal of immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  5. The immune response to SARS-CoV-2 in people with HIV.Cellular & molecular immunology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Michele SpinicciDepartment of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
Alessio MazzoniDepartment of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
Beatrice BorchiInfectious and Tropical Diseases Unit, Careggi University Hospital, Florence, Italy.
Lucia GrazianiDepartment of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
Marcello MazzettiInfectious and Tropical Diseases Unit, Careggi University Hospital, Florence, Italy.
Filippo BartalesiInfectious and Tropical Diseases Unit, Careggi University Hospital, Florence, Italy.
Annarita BottaDepartment of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
Marta TilliDepartment of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
Filippo PieralliIntermediate Care Unit, Careggi University Hospital, Florence, Italy.
Marco CoppiDepartment of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
Nicla GiovacchiniDepartment of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
Maria Grazia ColaoMicrobiology and Virology Unit, Careggi University Hospital, Florence, Italy.
Riccardo SaccardiDepartment of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
Gian Maria RossoliniDepartment of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
Francesco AnnunziatoDepartment of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
Alessandro BartoloniDepartment of Experimental and Clinical Medicine, University of Florence, Florence, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A late presenter AIDS patient with severe T cell depletion presented non-severe COVID-19 symptoms, with prolonged viral shedding. Our case report supports the hypothesis that an effective T cell response may be dispensable for the control of COVID-19 progression to severe forms, while it may be necessary for SARS-CoV-2 clearance.

Indexed as

Acquired Immunodeficiency SyndromeAdultCD4 Lymphocyte CountCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCOVID-19FemaleHumansSARS-CoV-2CD4convalescent plasmaCOVID-19HIVimmunocompromisedmonoclonal

Identifiers

PMID34822185
PMCPMC9015404

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.