Evidence map›Paper›PMID 34822111›Full record

ArticleNeotropical entomology2022

Biosynthesized Gold Nanoparticles Integrated Ointment Base for Repellent Activity Against Aedes aegypti L.

Balasubramani Sundararajan, Gnanasekar Sathishkumar, Prabu Kumar Seetharaman, Anil Kumar Moola, Saravanamoorthy Mutharasanallur Duraisamy, Al Anoud Saud Bin Mutayran, Vidya Devanathadesikan Seshadri, Adelina Thomas, Bollipo Diana Ranjitha Kumari, Sivaperumal Sivaramakrishnan and 2 more

Abstract read
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In one paragraph

Article in Neotropical entomology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.3field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Laboratory evaluation of the toxicity of selenium and gold nanoparticles against the housefly (Veterinary research forum : an international quarterly journal · 2026
    Article
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 4 countries.

Balasubramani SundararajanCollege of Horticulture and Landscape Architecture, Southwest University, Chongqing, People's Republic of China. sundarpbt87@gmail.com.
Gnanasekar SathishkumarSchool of Materials and Energy, Southwest University, Chongqing, People's Republic of China.
Prabu Kumar SeetharamanDept of Biotechnology, Bharathidasan University, Tiruchirappalli, Tamil Nadu, India.
Anil Kumar MoolaDept of Biotechnology, Aditya Degree and PG College, Kakinada, Andhra Pradesh, India.
Saravanamoorthy Mutharasanallur DuraisamyDept of Botany, Arignar Anna Govt Arts College, Musiri, Tiruchirappalli, Tamil Nadu, India.
Al Anoud Saud Bin MutayranCollege of Pharmacy (Girls), Prince Sattam Bin Abdulaziz University, Al-Kharj, Kingdom of Saudi Arabia.
Vidya Devanathadesikan SeshadriCollege of Pharmacy (Girls), Prince Sattam Bin Abdulaziz University, Al-Kharj, Kingdom of Saudi Arabia.
Adelina ThomasSchool of Pharmacy, Catholic University of Health and Allied Sciences, Mwanza, Tanzania.
Bollipo Diana Ranjitha KumariDept of Botany, Bharathidasan University, Tiruchirappalli, Tamil Nadu, India.
Sivaperumal SivaramakrishnanDept of Biotechnology, Bharathidasan University, Tiruchirappalli, Tamil Nadu, India.
Eliningaya J KwekaDivision of Livestock and Human Diseases Vector Control, Mosquito Section, Tropical Pesticides Research Institute, Arusha, Tanzania.
Zhiqin ZhouCollege of Horticulture and Landscape Architecture, Southwest University, Chongqing, People's Republic of China. zhouzhiqin@swu.edu.cn.
Bharathidasan University · INSouthwest University · CNPrince Sattam Bin Abdulaziz University · SAAditya Birla (India) · INCatholic University of Health and Allied Sciences · TZTropical Pesticides Research Institute · TZ

Funding

University Grants Commission UGC letter No. F.No.42-922/2013 SR
6 · The paper itself

Abstract

The present study focused on preparing a nano-ointment base integrated with biogenic gold nanoparticles from Artemisia vulgaris L. leaf extract. As prepared, nano-ointment was characterized by using Fourier-transform infrared spectroscopy, and the morphology of the nano-ointment was confirmed through a scanning electron microscope. Initially, the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide results showed nano-ointment cytocompatibility at different concentrations (20-200 μg/mL) against L929 cells. The in vitro hemolysis assay also revealed that the nano-ointment is biocompatible. Further studies confirmed that nano-ointment has repellent activity with various concentrations (12.5, 25, 50, 75, and 100 ppm). At 100 ppm concentration, the highest repellent activity was observed at 60-min protection time against the Aedes aegypti L. female mosquitoes. The results indicated that the increasing concentration of nano-ointment prolongs the protection time. Moreover, the outcome of this study provides an alternative nano-ointment to synthetic repellent and insecticides after successful clinical trials. It could be an eco-friendly, safer nano-bio repellent, which can protect from dengue fever mosquitoes.

Indexed as

AedesAnophelesInsecticidesMetal NanoparticlesAnimalsGoldLarvaOintment BasesPlant ExtractsPlant LeavesGoldInsecticidesOintment BasesPlant ExtractsGold nanoparticlesL929 cellsRepellentScanning electron microscope

Identifiers

PMID34822111
OpenAlexW3216164302

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.