Evidence map›Paper›PMID 34822101›Full record

ArticleLa Radiologia medica2022

A non-invasive, automated diagnosis of Menière's disease using radiomics and machine learning on conventional magnetic resonance imaging: A multicentric, case-controlled feasibility study.

Marly F J A van der Lubbe, Akshayaa Vaidyanathan, Marjolein de Wit, Elske L van den Burg, Alida A Postma, Tjasse D Bruintjes, Monique A L Bilderbeek-Beckers, Patrick F M Dammeijer, Stephanie Vanden Bossche, Vincent Van Rompaey and 3 more

Open access · hybridAbstract readMulticenter Study
In one paragraph

Article in La Radiologia medica, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.

  1. Potential Application of Hydrops MR Imaging: A Systematic Review.Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
    Pooled it
  2. Article
  3. Article
  4. Insights into radiomics: a comprehensive review for beginners.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025
    Review
  5. The Endolymph Signal in Non-contrast Enhanced 3D-real IR Image Differs between the Ears with and without Significant Endolymphatic Hydrops.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2025
    Article
  6. Review
  7. [Artificial intelligence applications in Ménière's disease].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2025
    Review
  8. Review
  9. Applications of Machine Learning in Meniere's Disease Assessment Based on Pure-Tone Audiometry.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2025
    Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Peritoneal Carcinosis: What the Radiologist Needs to Know.Diagnostics (Basel, Switzerland) · 2023
    Review
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 2 countries.

Marly F J A van der LubbeDepartment of Otolaryngology and Head and Neck Surgery, Maastricht University Medical Center +, Maastricht, The Netherlands. marly.lubbe@mumc.nl.ORCID http://orcid.org/0000-0001-9629-5509
Akshayaa VaidyanathanThe D-Lab, Department of Precision Medicine, GROW Research Institute for Oncology, Maastricht University, Maastricht, The Netherlands.
Marjolein de WitDepartment of Otolaryngology and Head and Neck Surgery, Maastricht University Medical Center +, Maastricht, The Netherlands.
Elske L van den BurgDepartment of Otolaryngology and Head and Neck Surgery, Maastricht University Medical Center +, Maastricht, The Netherlands.
Alida A PostmaDepartment of Radiology and Nuclear Medicine, Maastricht University Medical Center, Maastricht, The Netherlands.
Tjasse D BruintjesDepartment of Otorhinolaryngology, Gelre Hospital, Apeldoorn, The Netherlands.
Monique A L Bilderbeek-BeckersDepartment of Radiology, Viecuri Medical Center, Venlo, The Netherlands.
Patrick F M DammeijerDepartment of Otorhinolaryngology, Viecuri Medical Center, Venlo, The Netherlands.
Stephanie Vanden BosscheDepartment of Radiology, Antwerp University Hospital, Antwerp, Belgium.
Vincent Van RompaeyDepartment of Otorhinolaryngology and Head & Neck Surgery, Antwerp University Hospital, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium.
Philippe LambinThe D-Lab, Department of Precision Medicine, GROW Research Institute for Oncology, Maastricht University, Maastricht, The Netherlands.
Marc van Hoof *Department of Otolaryngology and Head and Neck Surgery, Maastricht University Medical Center +, Maastricht, The Netherlands.
Raymond van de Berg *Department of Otolaryngology and Head and Neck Surgery, Maastricht University Medical Center +, Maastricht, The Netherlands.
Maastricht University · NLVieCuri Medisch Centrum · NLAntwerp University Hospital · BELeiden University Medical Center · NLMaastricht University Medical Centre · NLUniversity of Antwerp · BE

Funding

European Research Council n° 694812H2020 Society () n° 766276
6 · The paper itself

Abstract

purposeThis study investigated the feasibility of a new image analysis technique (radiomics) on conventional MRI for the computer-aided diagnosis of Menière's disease. MATERIALS AND

methodsA retrospective, multicentric diagnostic case-control study was performed. This study included 120 patients with unilateral or bilateral Menière's disease and 140 controls from four centers in the Netherlands and Belgium. Multiple radiomic features were extracted from conventional MRI scans and used to train a machine learning-based, multi-layer perceptron classification model to distinguish patients with Menière's disease from controls. The primary outcomes were accuracy, sensitivity, specificity, positive predictive value, and negative predictive value of the classification model.

resultsThe classification accuracy of the machine learning model on the test set was 82%, with a sensitivity of 83%, and a specificity of 82%. The positive and negative predictive values were 71%, and 90%, respectively.

conclusionThe multi-layer perceptron classification model yielded a precise, high-diagnostic performance in identifying patients with Menière's disease based on radiomic features extracted from conventional T2-weighted MRI scans. In the future, radiomics might serve as a fast and noninvasive decision support system, next to clinical evaluation in the diagnosis of Menière's disease.

Indexed as

Machine LearningAdolescentAdultAgedAged, 80 and overCase-Control StudiesEar, InnerFeasibility StudiesFemaleHumansImage Interpretation, Computer-AssistedMagnetic Resonance ImagingMaleMeniere DiseaseMiddle AgedRetrospective StudiesMachine learningMagnetic resonance imagingMenière’s diseaseRadiomics

Identifiers

PMID34822101
PMCPMC8795017
OpenAlexW3215923326

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.