ReviewJournal of biological physics2022
Perspectives on the landscape and flux theory for describing emergent behaviors of the biological systems.
Review in Journal of biological physics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Exploring Neurofunctional Phase Transition Patterns in Autism Spectrum Disorder via Thermodynamics Parameters.Entropy (Basel, Switzerland) · 2026Article
- Cell condensation initiates organogenesis: the role of actin dynamics in supracellular self-organizing process.Cell & bioscience · 2025Review
- Finding signatures of low-dimensional geometric landscapes in high-dimensional cell fate transitions.bioRxiv : the preprint server for biology · 2025Article
- Finding signatures of low-dimensional geometric landscapes in high-dimensional cell fate transitions.ArXiv · 2025Article
- Understanding underlying physical mechanism reveals early warning indicators and key elements for adaptive infections disease networks.PNAS nexus · 2024Article
Corrections and comments
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Authors and funding
1 author.
Funding
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Abstract
We give a review on the landscape theory of the equilibrium biological systems and landscape-flux theory of the nonequilibrium biological systems as the global driving force. The emergences of the behaviors, the associated thermodynamics in terms of the entropy and free energy and dynamics in terms of the rate and paths have been quantitatively demonstrated. The hierarchical organization structures have been discussed. The biological applications ranging from protein folding, biomolecular recognition, specificity, biomolecular evolution and design for equilibrium systems as well as cell cycle, differentiation and development, cancer, neural networks and brain function, and evolution for nonequilibrium systems, cross-scale studies of genome structural dynamics and experimental quantifications/verifications of the landscape and flux are illustrated. Together, this gives an overall global physical and quantitative picture in terms of the landscape and flux for the behaviors, dynamics and functions of biological systems.
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