Evidence map›Paper›PMID 34822056›Full record

ArticleHepatology international2022

Longitudinal renal changes in chronic hepatitis B patients treated with entecavir versus TDF: a REAL-B study.

Lung-Yi Mak, Joseph Hoang, Dae Won Jun, Chien-Hung Chen, Cheng-Yuan Peng, Ming-Lun Yeh, Sung Eun Kim, Daniel Q Huang, Jae Yoon Jeong, Eileen Yoon and 32 more

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Article in Hepatology international, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 21 citations in OpenAlex.

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  6. Current status of drug therapy for chronic hepatitis B.World journal of gastroenterology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

42 authors at 20 institutions in 7 countries.

Lung-Yi Mak *Department of Medicine, the University of Hong Kong, Hong Kong SAR, China.
Joseph Hoang *Division of Gastroenterology and Hepatology, Stanford University Medical Center, Palo Alto, CA, USA.
Dae Won JunDepartment of Internal Medicine, Hanyang University Hospital, Hanyang University College of Medicine, Seoul, South Korea.
Chien-Hung ChenDepartment of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.
Cheng-Yuan PengDepartment of Gastroenterology, China Medical University Hospital, Taichung, Taiwan.
Ming-Lun YehDepartment of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
Sung Eun KimDepartment of Internal Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, China.
Daniel Q HuangDepartment of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Jae Yoon JeongDepartment of Internal Medicine, National Medical Center, Seoul, South Korea.
Eileen YoonDepartment of Internal Medicine, Sanggye Paik Hospital, Inje University Seoul, Seoul, South Korea.
Hyunwoo OhDepartment of Internal Medicine, Hanyang University Hospital, Hanyang University College of Medicine, Seoul, South Korea.
Pei-Chien TsaiDepartment of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
Chung-Feng HuangDepartment of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
Sang Bong AhnDepartment of Internal Medicine, Nowon Eulji Medical Center, Eulji University College of Medicine, Seoul, South Korea.
Huy TrinhSan Jose Gastroenterology, San Jose, CA, USA.
Qing XieDepartment of Infectious Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.
Grace L H WongDepartment of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China.
Masaru EnomotoDepartment of Hepatology, Graduate School of Medicine, Osaka City University, Osaka, Japan.
Jae-Jun ShimDepartment of Internal Medicine, Kyung Hee University Hospital, Kyung Hee University School of Medicine, Seoul, South Korea.
Dong-Hyun LeeDepartment of Gastroenterology, Good Gang-An Hospital, Busan, South Korea.
Li LiuDepartment of Infection Disease, The Third Hospital of Kumming City, Kumming, People's Republic of China.
Ritsuzo KozukaDepartment of Hepatology, Graduate School of Medicine, Osaka City University, Osaka, Japan.
Yong Kyun ChoDepartment of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea.
Soung Won JeongDepartment of Internal Medicine, Soonchunhyang University Hospital, Soonchunhyang University College of Medicine, Seoul, South Korea.
Hyoung Su KimDepartment of Internal Medicine, Hallym University Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Seoul, South Korea.
Lindsey TrinhDivision of Gastroenterology and Hepatology, Stanford University Medical Center, Palo Alto, CA, USA.
Allen DaoDivision of Gastroenterology and Hepatology, Stanford University Medical Center, Palo Alto, CA, USA.
Rui HuangDepartment of Infectious Diseases, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, Jiangsu, People's Republic of China.
Rex Wan-Hin HuiDepartment of Medicine, the University of Hong Kong, Hong Kong SAR, China.
Vivien TsuiDepartment of Medicine, the University of Hong Kong, Hong Kong SAR, China.
Sabrina QuekDepartment of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Htet Htet Toe Wai KhineDepartment of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Eiichi OgawaDepartment of General Internal Medicine, Kyushu University Hospital, Fukuoka, Japan.
Chia Yen DaiDepartment of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
Jee Fu HuangDepartment of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
Ramsey CheungDivision of Gastroenterology and Hepatology, Stanford University Medical Center, Palo Alto, CA, USA.
Chao WuDepartment of Infectious Diseases, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, Jiangsu, People's Republic of China.
Wan-Long ChuangDepartment of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
Seng Gee LimDepartment of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Ming-Lung YuDepartment of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
Man-Fung YuenDepartment of Medicine, the University of Hong Kong, Hong Kong SAR, China. mfyuen@hkucc.hku.hk.
Mindie H NguyenDivision of Gastroenterology and Hepatology, Stanford University Medical Center, Palo Alto, CA, USA. mindiehn@stanford.edu.ORCID http://orcid.org/0000-0002-6275-4989
Kaohsiung Medical University · TWChinese University of Hong Kong · HKNational University of Singapore · SGStanford Medicine · USHanyang University Seoul Hospital · KRNanjing Drum Tower Hospital · CNOsaka City University · JPChang Gung University · TWChina Medical University · TWEulji University · KRHallym University · KRInje University Sanggye Paik Hospital · KRKangbuk Samsung Hospital · KRKunming Third People's Hospital · CNKyung Hee University · KRKyushu University Hospital · JPNational Medical Center · KRShanghai Jiao Tong University · CNSoonchunhyang University Hospital Seoul · KRStanford Health Care · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimsWe aimed to compare the longitudinal changes in estimated glomerular filtration rate (eGFR) in chronic hepatitis B (CHB) patients treated with entecavir (ETV) vs. tenofovir disoproxil fumarate (TDF).

methodsThis is a retrospective study of 6189 adult treatment-naïve CHB patients initiated therapy with TDF (n = 2482) or ETV (n = 3707) at 25 international centers using multivariable generalized linear modeling (GLM) to determine mean eGFR (mL/min/1.73 m

resultsIn the overall cohort (mean age 49.7 years, 66.2% male), the baseline eGFR was higher for TDF vs. ETV group (75.9 vs. 74.0, p = 0.009). PSM yielded 1871 pairs of ETV or TDF patients with baseline eGFR ≥ 60 and 520 pairs for the eGFR < 60 group. GLM analysis of the overall (unmatched) cohort and PSM cohorts revealed lower adjusted mean eGFRs in TDF (vs. ETV) patients (all p < 0.01) during 10 years of follow-up. Among PSM eGFR ≥ 60 patients, the 5-year cumulative incidences of renal impairment were 42.64% for ETV and 48.03% for TDF (p = 0.0023). In multivariable Cox regression, TDF vs. ETV (adjusted HR 1.26, 95% CI 1.11-1.43) was associated with higher risk of worsening renal function.

conclusionOver the 10-year study follow-up, compared to ETV, TDF was associated with a lower mean eGFR and higher incidence of renal impairment.

Indexed as

Hepatitis B, ChronicAdultAntiviral AgentsFemaleGuanineHumansKidneyMaleMiddle AgedRetrospective StudiesTenofovirTreatment OutcomeAntiviral AgentsentecavirGuanineTenofovirChronic kidney diseaseLong-term follow-upReal-world studyRenal function

Identifiers

PMID34822056
OpenAlexW3215716159

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.