Evidence map›Paper›PMID 34822038›Full record

ArticleJournal of medical systems2021

The Impact of Functional Dependence and Related Surgical Complications on Postoperative Mortality.

Jacob C Clifton, Milo Engoren, Matthew S Shotwell, Barbara J Martin, Elise M Clemens, Oscar D Guillamondegui, Robert E Freundlich

Open access · greenAbstract read
In one paragraph

Article in Journal of medical systems, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Observational
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Jacob C CliftonDepartment of Anesthesiology, Vanderbilt University Medical Center, 1211 21 St Ave. S, Nashville, TN, 37212, USA. jacob.c.clifton@vumc.org.
Milo EngorenDepartment of Anesthesiology, University of Michigan, Ann Arbor, MI, USA.
Matthew S ShotwellDepartment of Anesthesiology, Vanderbilt University Medical Center, 1211 21 St Ave. S, Nashville, TN, 37212, USA.
Barbara J MartinDepartment of Quality, Safety and Risk Prevention, Vanderbilt University Medical Center, Nashville, TN, USA.
Elise M ClemensDepartment of Anesthesiology, University of North Carolina, Chapel Hill, NC, USA.
Oscar D GuillamondeguiDepartment of Surgery, Vanderbilt University Medical Center, Nashville, TN, USA.
Robert E FreundlichDepartment of Anesthesiology, Vanderbilt University Medical Center, 1211 21 St Ave. S, Nashville, TN, 37212, USA.
Vanderbilt University Medical Center · USUniversity of Michigan–Ann Arbor · USUniversity of North Carolina at Chapel Hill · US

Funding

Institutional Career Development CoreKL2TR002245 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Julie A. Bastarache · 2017 to 2026
$9.3M
Reducing Reintubation Risk in High-Risk Cardiac Surgery Patients with High-Flow Nasal Cannula -the "I-CAN" studyK23HL148640 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI FREUNDLICH, ROBERT EDWARD · 2020 to 2024
$867k
NCATS NIH HHS KL2 TR002245NHLBI NIH HHS K23 HL148640NHLBI NIH HHS K23HL148640
6 · The paper itself

Abstract

purposeFunctional dependency is a known determinant of surgical risk. To enhance our understanding of the relationship between dependency and adverse surgical outcomes, we studied how postoperative mortality following a surgical complication was impacted by preoperative functional dependency.

methodsWe explored a historical cohort of 6,483,387 surgical patients within the American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP). All patients ≥ 18 years old within the ACS-NSQIP from 2007 to 2017 were included.

resultsThere were 6,222,611 (96.5%) functionally independent, 176,308 (2.7%) partially dependent, and 47,428 (0.7%) totally dependent patients. Within 30 days postoperatively, 57,652 (0.9%) independent, 15,075 (8.6%) partially dependent, and 10,168 (21.4%) totally dependent patients died. After adjusting for confounders, increasing functional dependency was associated with increased odds of mortality (Partially Dependent OR: 1.72, 99% CI: 1.66 to 1.77; Totally Dependent OR: 2.26, 99% CI: 2.15 to 2.37). Dependency also significantly impacted mortality following a complication; however, independent patients usually experienced much stronger increases in the odds of mortality. There were six complications not associated with increased odds of mortality. Model diagnostics show our model was able to distinguish between patients who did and did not suffer 30-day postoperative mortality nearly 96.7% of the time.

conclusionsWithin our cohort, dependent surgical patients had higher rates of comorbidities, complications, and odds of 30-day mortality. Preoperative functional status significantly impacted the level of postoperative mortality following a complication, but independent patients were most affected.

Indexed as

Functional StatusPostoperative ComplicationsAdolescentCohort StudiesComorbidityHumansQuality ImprovementRetrospective StudiesRisk FactorsFunctional dependency statusPostoperative mortalityRisk assessmentSurgical complication

Identifiers

PMID34822038
PMCPMC8709534
OpenAlexW3216360311

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.