Evidence map›Paper›PMID 34822018›Full record

ReviewEuropean spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society2022

Establishment and validation of a nomogram and web calculator for the risk of new vertebral compression fractures and cement leakage after percutaneous vertebroplasty in patients with osteoporotic vertebral compression fractures.

Wenle Li, Haosheng Wang, Shengtao Dong, Zhi-Ri Tang, Longhao Chen, Xintian Cai, Zhaohui Hu, Chengliang Yin

Open access · hybridAbstract readReview
PubMed Publisher
In one paragraph

Review in European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed, 9 pooled it
10.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 9 syntheses or guidelines pooled it, 70 citations in OpenAlex.

  1. Pooled it
  2. Risk factors for refracture after vertebral augmentation in postmenopausal women with osteoporotic vertebral compression fractures: a systematic review and meta-analysis.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026
    Pooled it
  3. The establishment and validation of a risk appraisal model for cement leakage after percutaneous vertebral augmentation for osteoporotic vertebral compression fractures based on a meta-analysis.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026
    Pooled it
  4. Pooled it
  5. Risk factors for new vertebral fracture after percutaneous vertebroplasty or kyphoplasty for osteoporotic vertebral compression fractures (OVCFs): an updated systematic review and meta-analysis.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2025
    Pooled it
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  10. Trial
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  15. Incidence and risk factors of subsequent vertebral fracture following percutaneous vertebral augmentation in postmenopausal women.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026
    Article
  16. External validation of predictive models for new vertebral fractures following percutaneous vertebroplasty.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026
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  20. A nomogram for predicting fracture of the sandwich vertebrae after percutaneous vertebral augmentation: a multicenter study with 1-year follow-up.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026
    Article

2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 8 institutions in 1 country.

Wenle Li *Department of Orthopedics, Xianyang Central Hospital, Xianyang, 712000, China.
Haosheng Wang *Orthopaedic Medical Center, The Second Hospital of Jilin University, Changchun, 130000, China.
Shengtao Dong *Department of Spine Surgery, Second Affiliated Hospital of Dalian Medical University, Dalian, 116000, China.
Zhi-Ri TangSchool of Physics and Technology, Wuhan University, Wuhan, 430072, China.
Longhao ChenGraduate School, Guangxi University of Chinese Medicine, Nanning, 530000, China.
Xintian CaiHypertension Center of People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, 830001, China.
Zhaohui HuDepartment of Spinal Surgery, Liuzhou People's Hospital, Liuzhou, 545000, China. 329870376@qq.com.
Chengliang YinNational Engineering Laboratory for Medical Big Data Application Technology, Chinese PLA General Hospital, Beijing, 1000853, China. chengliangyin@163.com.
Chinese PLA General Hospital · CNGuangxi University · CNLiuzhou General Hospital · CNPeople's Hospital of Xinjiang Uygur Autonomous Region · CNSecond Affiliated Hospital of Dalian Medical University · CNSecond Affiliated Hospital of Jilin University · CNWuhan University · CNXian Yang Central Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe aim of this work was to investigate the risk factors for cement leakage and new-onset OVCF after Percutaneous vertebroplasty (PVP) and to develop and validate a clinical prediction model (Nomogram).

methodsPatients with Osteoporotic VCF (OVCF) treated with PVP at Liuzhou People's Hospital from June 2016 to June 2018 were reviewed and met the inclusion criteria. Relevant data affecting bone cement leakage and new onset of OVCF were collected. Predictors were screened using univariate and multi-factor logistic analysis to construct Nomogram and web calculators. The consistency of the prediction models was assessed using calibration plots, and their predictive power was assessed by tenfold cross-validation. Clinical value was assessed using Decision curve analysis (DCA) and clinical impact plots.

resultsHigher BMI was associated with lower bone mineral density (BMD). Higher BMI, lower BMD, multiple vertebral fractures, no previous anti-osteoporosis treatment, and steroid use were independent risk factors for new vertebral fractures. Cement injection volume, time to surgery, and multiple vertebral fractures were risk factors for cement leakage after PVP. The development and validation of the Nomogram also demonstrated the predictive ability and clinical value of the model.

conclusionsThe established Nomogram and web calculator (https://dr-lee.shinyapps.io/RefractureApp/) (https://dr-lee.shinyapps.io/LeakageApp/) can effectively predict the occurrence of cement leakage and new OVCF after PVP.

Indexed as

Fractures, CompressionOsteoporotic FracturesSpinal FracturesVertebroplastyBone CementsHumansModels, StatisticalNomogramsPrognosisRetrospective StudiesRisk FactorsTreatment OutcomeBone CementsBone cement leakageNomogramOsteoporotic compression fracturesPercutaneous vertebroplastyRisk factorsWeb calculator

Identifiers

PMID34822018
OpenAlexW3214744487

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.