Evidence map›Paper›PMID 34821638›Full record

ArticleBiosensors2021

DNAzyme-Amplified Label-Free Biosensor for the Simple and Sensitive Detection of Pyrophosphatase.

Cheng-Yu Lee, Chi-Hsiang Liao, Nei-Mei Fang, You-Zung Hsieh

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biosensors, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Cheng-Yu LeeDepartment of Applied Chemistry, National Yang Ming Chiao Tung University, Hsinchu 300, Taiwan.
Chi-Hsiang LiaoDepartment of Applied Chemistry, National Yang Ming Chiao Tung University, Hsinchu 300, Taiwan.
Nei-Mei FangDepartment of Applied Chemistry, National Yang Ming Chiao Tung University, Hsinchu 300, Taiwan.
You-Zung HsiehDepartment of Applied Chemistry, National Yang Ming Chiao Tung University, Hsinchu 300, Taiwan.ORCID 0000-0002-2625-0409
National Yang Ming Chiao Tung University · TW

Funding

Ministry of Education (MOE) in Taiwan, R.O.C. the Center for Emergent Functional Matter Science of National Yang Ming Chiao Tung University-from the Featured Areas Research Center Program within the framework of the Higher Education Sprout ProjectMinistry of Science and Technology, Taiwan MOST 109-2113-M-009-014
6 · The paper itself

Abstract

The level of pyrophosphatase (PPase) expression has been suggested as a potential biomarker of various cancers, and its prognostic value has been evaluated in patients suffering from lung cancer, colorectal cancer, and hyperthyroidism. However, the detection of PPase usually needs specific materials that require complicated, time-consuming reactions with restricted linear range and sensitivity, limiting their application in early clinical diagnosis. Herein, we developed a DNAzyme-based biosensor for the detection of PPase. In the presence of PPase, pyrophosphate (PPi) and Cu

Indexed as

Biosensing TechniquesDNA, CatalyticFluorescent DyesHumansPyrophosphatasesDNA, CatalyticFluorescent DyesPyrophosphatasesAP siteATMNDbiosensorDNAzymePPase

Identifiers

PMID34821638
PMCPMC8615721
OpenAlexW3210382462

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.