Evidence map›Paper›PMID 34821628›Full record

ReviewBiosensors2021

A Review of Advanced Impedance Biosensors with Microfluidic Chips for Single-Cell Analysis.

Soojung Kim, Hyerin Song, Heesang Ahn, Taeyeon Kim, Jihyun Jung, Soo Kyung Cho, Dong-Myeong Shin, Jong-Ryul Choi, Yoon-Hwae Hwang, Kyujung Kim

Abstract readReview
In one paragraph

Review in Biosensors, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Soojung KimDepartments of Congo-Mechatronics Engineering, Pusan National University, Busan 46241, Korea.
Hyerin SongDepartments of Congo-Mechatronics Engineering, Pusan National University, Busan 46241, Korea.
Heesang AhnDepartments of Congo-Mechatronics Engineering, Pusan National University, Busan 46241, Korea.
Taeyeon KimDepartments of Congo-Mechatronics Engineering, Pusan National University, Busan 46241, Korea.
Jihyun JungDepartments of Congo-Mechatronics Engineering, Pusan National University, Busan 46241, Korea.ORCID 0000-0003-3083-4615
Soo Kyung ChoDivision of Nano Convergence Technology, Pusan National University (PNU), Miryang 50463, Korea.
Dong-Myeong ShinDepartment of Mechanical Engineering, The University of Hong Kong, Pokfulam, Hong Kong 999077, China.ORCID 0000-0002-5402-9947
Jong-Ryul ChoiMedical Device Development Center, Daegu-Gyeongbuk Medical Innovation Foundation (DGMIF), Daegu 41061, Korea.ORCID 0000-0002-6645-6399
Yoon-Hwae HwangDepartment of Nano Energy Engineering, Pusan National University (PNU), Busan 46241, Korea.ORCID 0000-0002-1982-2210
Kyujung KimDepartments of Congo-Mechatronics Engineering, Pusan National University, Busan 46241, Korea.

Funding

National Research Foundation of Korea 2017M3D1A1039287National Research Foundation of Korea 2020R1A2C2007590National Research Foundation of Korea 2020R1A2C4002732National Research Foundation of Korea 2021R1A4A2001827
6 · The paper itself

Abstract

Electrical impedance biosensors combined with microfluidic devices can be used to analyze fundamental biological processes for high-throughput analysis at the single-cell scale. These specialized analytical tools can determine the effectiveness and toxicity of drugs with high sensitivity and demonstrate biological functions on a single-cell scale. Because the various parameters of the cells can be measured depending on methods of single-cell trapping, technological development ultimately determine the efficiency and performance of the sensors. Identifying the latest trends in single-cell trapping technologies afford opportunities such as new structural design and combination with other technologies. This will lead to more advanced applications towards improving measurement sensitivity to the desired target. In this review, we examined the basic principles of impedance sensors and their applications in various biological fields. In the next step, we introduced the latest trend of microfluidic chip technology for trapping single cells and summarized the important findings on the characteristics of single cells in impedance biosensor systems that successfully trapped single cells. This is expected to be used as a leading technology in cell biology, pathology, and pharmacological fields, promoting the further understanding of complex functions and mechanisms within individual cells with numerous data sampling and accurate analysis capabilities.

Indexed as

Biosensing TechniquesMicrofluidic Analytical TechniquesMicrofluidicsSingle-Cell AnalysisElectric ImpedanceLab-On-A-Chip Devicesbiosensorimpedance sensormicrofluidic chipsingle cell trapping

Identifiers

PMID34821628
PMCPMC8615569

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.