Evidence map›Paper›PMID 34821472›Full record

ArticleThoracic cancer2022

Onset of pulmonary Epstein-Barr virus-positive diffuse large B-cell lymphoma in a patient with silicosis.

Ryosuke Ogata, Hiroshi Soda, Yasuhiro Tanaka, Hiroaki Senju, Midori Shimada, Koki Yamashita, Shota Nakashima, Asuka Umemura, Masataka Yoshida, Takuya Hara and 5 more

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Thoracic cancer, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Ryosuke OgataDepartment of Respiratory Medicine, Sasebo City General Hospital, Nagasaki, Japan.
Hiroshi SodaDepartment of Respiratory Medicine, Sasebo City General Hospital, Nagasaki, Japan.ORCID 0000-0003-4993-1837
Yasuhiro TanakaDepartment of Respiratory Medicine, Sasebo City General Hospital, Nagasaki, Japan.
Hiroaki SenjuDepartment of Respiratory Medicine, Sasebo City General Hospital, Nagasaki, Japan.
Midori ShimadaDepartment of Respiratory Medicine, Sasebo City General Hospital, Nagasaki, Japan.
Koki YamashitaDepartment of Respiratory Medicine, Sasebo City General Hospital, Nagasaki, Japan.
Shota NakashimaDepartment of Respiratory Medicine, Sasebo City General Hospital, Nagasaki, Japan.
Asuka UmemuraDepartment of Respiratory Medicine, Sasebo City General Hospital, Nagasaki, Japan.
Masataka YoshidaDepartment of Respiratory Medicine, Sasebo City General Hospital, Nagasaki, Japan.
Takuya HaraDepartment of Pathology, Sasebo City General Hospital, Nagasaki, Japan.
Saeko JinnaiDepartment of Pathology, Sasebo City General Hospital, Nagasaki, Japan.
Keisuke IwasakiDepartment of Pathology, Sasebo City General Hospital, Nagasaki, Japan.
Yuichi FukudaDepartment of Respiratory Medicine, Sasebo City General Hospital, Nagasaki, Japan.
Hiroyuki YamaguchiDepartment of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Hiroshi MukaeDepartment of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Sasebo City General Hospital · JPNagasaki University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

How Epstein-Barr virus (EBV)-positive diffuse large B-cell lymphoma (DLBCL) occasionally occurs following chronic inflammation remains to be elucidated. The case of a 57-year-old man who developed pulmonary EBV-positive DLBCL from underlying silicosis lesions is presented. Immunohistochemical examination of the resected silicosis lesions showed predominant helper T cells and M1/M2 macrophages, with a lack of B cells, regulatory T cells, and resident memory T cells. Two years later, EBV-positive DLBCL emerged unexpectedly from the silicosis. The imbalance of the immune cells in the microenvironment, at least in part, may help explain how chronic inflammation contributes to EBV-positive DLBCL.

Indexed as

Epstein-Barr Virus InfectionsFatal OutcomeHerpesvirus 4, HumanHumansInhalation ExposureLymphoma, Large B-Cell, DiffuseMaleMiddle AgedOccupational DiseasesSilicosisTumor MicroenvironmentEpstein-Barr virusimmune cellslymphomasilicosis

Identifiers

PMID34821472
PMCPMC8720632
OpenAlexW3216859946

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.