Evidence map›Paper›PMID 34821434›Full record

ArticleEuropean journal of neurology2022

Reduction in cerebral oxygen metabolism in subcortical regions may be a biomarker of cognitive decline in people living with human immunodeficiency virus.

Souvik Sen, Hongyu An, Myriam Sollman, Jonathan Oakes, Joseph Eron, Kevin Robertson, William Powers

Abstract read
In one paragraph

Article in European journal of neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Souvik SenPrisma Health/University of South Carolina, Columbia, South Carolina, USA.ORCID 0000-0002-0886-2364
Hongyu AnWashington University, Saint Louis, Missouri, USA.
Myriam SollmanPrisma Health/University of South Carolina, Columbia, South Carolina, USA.
Jonathan OakesUniversity of North Carolina, Chapel Hill, North Carolina, USA.
Joseph EronUniversity of North Carolina, Chapel Hill, North Carolina, USA.
Kevin RobertsonUniversity of North Carolina, Chapel Hill, North Carolina, USA.
William PowersUniversity of North Carolina, Chapel Hill, North Carolina, USA.

Funding

Virology, Immunology, and Microbiology CoreP30AI050410 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAVID M. MARGOLIS · 2001 to 2026
$76.9M
Effect of HIV infection and antiretroviral therapy on cerebral autoregulationR01NS062754 · NINDS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SEN, SOUVIK · 2010 to 2014
$1.8M
NIAID NIH HHS P30 AI050410NINDS NIH HHS R01 NS062754
6 · The paper itself

Abstract

background and purposeRegional cerebral blood flow (rCBF) and oxygen metabolism (rCMRO

methodsTreatment-naïve PLHIV underwent neurocognitive assessment and magnetic resonance (MR) measurement of rCBF and rCMRO

resultsThirty PLHIV completed baseline and 12-month assessments (29 with rCMRO

conclusionsIn recently diagnosed PLHIV, no association was found between rCBF or rCMRO

Indexed as

Cognitive DysfunctionHIV InfectionsBiomarkersBrainCerebrovascular CirculationHIVHumansOxygenBiomarkersOxygenantiretroviral therapycerebral blood flowcerebral oxygen metabolismHANDHIV

Identifiers

PMID34821434
PMCPMC12226027

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.