Evidence map›Paper›PMID 34821064›Full record

ArticleInternational forum of allergy & rhinology2022

Circadian rhythm disruption exacerbates Th2-like immune response in murine allergic airway inflammation.

Feng-Li Cheng, Yun-Fang An, Jin-Mei Xue, Yan-Jie Wang, Xue-Wei Ding, Yan-Ting Zhang, Chang-Qing Zhao

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International forum of allergy & rhinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.

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  3. Circadian rhythms and lung cancer biology and immunotherapy: Emerging opportunities and challenges.Chinese medical journal pulmonary and critical care medicine · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Feng-Li ChengDepartment of Otolaryngology-Head and Neck Surgery, the Second Hospital, Shanxi Medical University, Taiyuan, China.ORCID 0000-0001-6833-2114
Yun-Fang AnDepartment of Otolaryngology-Head and Neck Surgery, the Second Hospital, Shanxi Medical University, Taiyuan, China.
Jin-Mei XueDepartment of Otolaryngology-Head and Neck Surgery, the Second Hospital, Shanxi Medical University, Taiyuan, China.
Yan-Jie WangDepartment of Otolaryngology-Head and Neck Surgery, the Second Hospital, Shanxi Medical University, Taiyuan, China.
Xue-Wei DingDepartment of Otolaryngology-Head and Neck Surgery, Huludao Central Hospital, Huludao, China.
Yan-Ting ZhangDepartment of Otolaryngology-Head and Neck Surgery, the Second Hospital, Shanxi Medical University, Taiyuan, China.
Chang-Qing ZhaoDepartment of Otolaryngology-Head and Neck Surgery, the Second Hospital, Shanxi Medical University, Taiyuan, China.
Shanxi Medical University · CNHue Central Hospital · VN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundChronic jet lag (CJL)-induced circadian rhythm disruption (CRD) is positively correlated with an increased risk of allergic diseases. However, little is known about the mechanism involved in allergic rhinitis (AR).

methodsAberrant light/dark cycles-induced CRD mice were randomly divided into negative control (NC) group, AR group, CRD+NC group, and CRD+AR group (n = 8/group). After ovalbumin (OVA) challenge, nasal symptom scores were recorded. The expression of Occludin and ZO-1 in both nasal mucosa and lung tissues was detected by reverse transcription-quantitative polymerase chain reaction (RT-PCR) and immunohistochemical staining. The level of OVA-specific immunoglobulin E (sIgE) and T-helper (Th)-related cytokines in the plasma was measured by enzyme-linked immunosorbent assay (ELISA), and the proportion of Th1, Th2, Th17, and regulatory T cell (Treg) in splenocytes was evaluated by flow cytometry.

resultsThe nasal symptom score in the CRD+AR group was significantly higher than those in the AR group with respect to eosinophil infiltration, mast cell degranulation, and goblet cell hyperplasia. The expression of ZO-1 and Occludin in the nasal mucosa and lung tissues in the CRD+AR group were significantly lower than those in the AR group. Furthermore, Th2 and Th17 cell counts from splenocytes and OVA-sIgE, interleukin 4 (IL-4), IL-6, IL-13, and IL-17A levels in plasma were significantly increased in the CRD+AR group than in the AR group, whereas Th1 and Treg cell count and interferon γ (IFN-γ) level were significantly decreased in the CRD+AR group.

conclusionCRD experimentally mimicked CJL in human activities, could exacerbate local and systemic allergic reactions in AR mice, partially through decreasing Occludin and ZO-1 level in the respiratory mucosa and increasing Th2-like immune response in splenocytes.

Indexed as

Circadian RhythmRhinitis, AllergicAnimalsDisease Models, AnimalImmunityImmunoglobulin EInflammationMiceMice, Inbred BALB COccludinImmunoglobulin EOccludinallergic rhinitiscircadian rhythm disruptionTh17Th2tight junction

Identifiers

PMID34821064
PMCPMC9298795
OpenAlexW3217263862

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.